The Powerful Anti-Aging Benefits of Spilanthol

Spilanthes acmella, commonly known as the toothache plant, is a flowering herb native to South America. For centuries, it has been used in traditional medicine due to its remarkable anti-inflammatory, analgesic, and antiseptic properties.  

More recently, Spilanthes acmella extract has gained recognition in the skincare industry for its powerful anti-aging benefits. Central to these benefits is Spilanthol, an active compound found in the plant, which offers a natural alternative to Botox, among other significant skin health improvements. 1 

Key Compounds in Spilanthes: 

Spilanthes acmella extract contains a variety of beneficial compounds, including triterpenes, sterols, polyphenols, and terpenoids. These compounds contribute to its anti-aging, anti-inflammatory, and antioxidant properties. Acmella oleracea flowers contain significant amounts of alkylamides, 3-acetylaleuritolic acid, β-sitostenone, scopoletin, vanillic acid, trans-ferulic acid, and trans-isoferulic acid. Spilanthol is the primary active ingredient responsible for the muscle-relaxing effects that help smooth the skin and reduce wrinkles. 2 3 

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Benefits of Acmella oleracea: 

Spilanthes acmella extract is suitable for all skin types, including sensitive and reactive skin. Its anti-inflammatory properties help to relieve allergic reactions and minimize irritation, resulting in an ideal choice for people with sensitive skin. The antioxidant properties protect against environmental damage, while the moisturizing components keep the skin hydrated, benefiting dry and oily skin types alike. 

There is some scientific evidence that the toothache plant contains therapeutic properties. It may help with the following conditions. 

Skin Benefits of Spillalthol: 

1. Spilanthes as a Natural Botox Alternative: 

One of the most notable applications of Spilanthes acmella extract is its use as a natural alternative to Botox. Spilanthol, the main component, works as a neuromodulator, relaxing facial muscles while decreasing wrinkles and fine lines. Unlike Botox, which requires injections, Spilanthol can be applied topically, making it a less invasive option for those seeking to maintain youthful skin. 4   

This study presents an ‘all-natural’ anti-wrinkle emulsion serum with Acmella oleracea extract, designed using a Design of Experiments (DoE) approach. The serum, formulated with a glycolipid emulsifier, was optimized for rheological properties and stability. In vivo tests on human volunteers demonstrated its safety and effectiveness, showing no skin irritation and a noticeable reduction in wrinkles after two weeks. The selected formulation contained 15% emollients and 1% emulsifier, balancing optimal viscosity, yield point, and minimal structural change, thus offering a natural, eco-friendly solution for improving facial fine lines and wrinkles. 5

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2. Anti-Inflammatory Properties: 

Spilanthol’s powerful anti-inflammatory properties help reduce inflammation and redness in the skin. This can significantly diminish signs of aging, wrinkles and fine lines produced by stress or damage by the environment. By calming the skin, Spilanthol also aids in alleviating conditions like acne and rosacea, making it suitable for sensitive skin types. 6 

In a vitro study, researchers studied spilanthol, a key compound in S. acmella, for its anti-inflammatory effects. They found that spilanthol reduced inflammation by blocking the production of inflammatory substances and by influencing specific genes. It also inhibited the activity of NF-κB, a key player in inflammation. Additionally, S. acmella was linked to increased levels of Nrf2, another protein that helps combat inflammation. 6 7

3. Antioxidant Properties:

The antioxidant properties of Spilanthol protect the skin from free radical damage, a major contributor to aging. Spilanthol, by counteracting unstable chemicals called free radicals, assists in preserving a youthful and radiant appearance by preventing damage to skin cells, which can result in the formation of wrinkles, fine lines, and age spots. Spilanthol, by neutralizing these harmful molecules, supports the preservation of a youthful and glowing complexion. 6 

A study on Spilanthes acmella extracts found that they induce vasorelaxation in rat thoracic aorta and have strong antioxidant properties. The ethyl acetate extract provides immediate vasorelaxation and high antioxidant activity, while the chloroform extract offers the highest vasorelaxation and antioxidation. These results suggest that Spilanthes acmella extracts could be potential sources of vasodilators and antioxidants. 8 

A recent study by Suwanjang et al. investigated if extracts from S. acmella could protect brain cells from pesticide damage. They tested these extracts on dopaminergic cells and found that they helped cells survive exposure to hydrogen peroxide or the pesticide pirimicarb. The hexane extract was especially effective against hydrogen peroxide. The researchers believe these benefits come from the antioxidants in S. acmella. 9  

4. Skin Hydrating Properties:

Spilanthes acmella extract is rich in hydrating compounds that keep the skin moisturized. Enough hydration is essential for maintaining skin elasticity and preventing dryness, which can accentuate wrinkles and make the skin appear older. Regular use of products containing Spilanthes extract can help keep the skin plump, soft, and youthful looking. 

5. Anti-Aging Benefits:

The combined anti-inflammatory, antioxidant, and moisturizing properties of Spilanthol make it a potent anti-aging ingredient. It boosts collagen production and shielding against damage caused by the environment, Spilanthol contributes to a smoother, firmer, and more youthful complexion. 

A study on urban Chinese women aged 20-45 found that a product with supramolecular retinol and acmella oleracea extract significantly reduced dark circles, fine wrinkles, and improved skin firmness over six weeks. Participants reported noticeable skin improvements, confirming the product’s effectiveness and good tolerance. 10  

Other Benefits of Acmella Extract: 

Acmella in Toothache: The toothache plant is used to relieve toothache pain. When chewed, it produces a numbing effect in the mouth. According to a 2013 review: Trusted Source, the plant’s principal active element, spilanthol, is responsible for its topical anesthetic effect. 11 

It also contains plant chemicals known as flavonoids. The flavonoids lower prostaglandins, which alter your experience of pain. 

Acmella in Dermatitis: The acmella’s anti-inflammatory qualities may help to treat dermatitis. This syndrome develops when the skin becomes irritated and puffy.

2019 animal research especially investigated this benefit. The researchers discovered that spilanthol inhibits the migration of inflammatory cells, producing an anti-inflammatory effect. This alleviates the edema associated with dermatitis. 12 

Act as a Diuretic: The tropical plant also serves as a natural diuretic. Diuretics help your body eliminate excess fluid by making you urinate more. 

This result was confirmed by a 2016 mouse study, which discovered that spilanthol increased urine production. The researchers discovered that spilanthol targets cellular functions in the kidneys involved in urine output and water reabsorption. 13 

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Gastric Ulcers: A 2014 animal study suggests that the toothache plant could aid in treating gastric ulcers. This plant contains a complex carbohydrate called rhamnogalacturonan (RGal), which boosts cell growth and reduces inflammation, potentially aiding in ulcer healing. 14 

For those looking to explore the benefits of this remarkable plant, products like Spilanthes Acmella Oleracea extract make it easy. With consistent application, you can see obvious improvements in the texture and appearance of your skin, allowing you to enjoy the youthful glow and other benefits you deserve. 

Note: While the information provided is based on credible references, we do not make any specific claims or guarantees. It is important to consult with your healthcare advisor for personalized advice and guidance related to your health.