Ezinye zezakhi ezicwaningwe kakhulu kwisayensi ye-nutraceutical, kusukela ku-curcumin kuya ku-CoQ10 kuya ku-vitamin C, zinesithiyo esifanayo: ukuzifaka egazini ngamanani abalulekile. Ukulethwa kwe-liposomal kungenye yezindlela zobuchwepheshe ezisetshenziswayo ukubhekana nalokhu, futhi yisayensi esekela ipulatifomu ye-NaturMed Scientific's LipoXbio™.
Kungani Ifomethi Yokulethwa Ibaluleke Kakhulu Njengesithako Ngokwaso
Isengezo sisebenza kahle kuphela njengenani lesakhi esisebenzayo esifinyelela ukujikeleza kwegazi. Izakhamzimba eziningi ezibalulekile kanye nezitshalo zihlukaniswa yi-asidi yesisu kanye nama-enzyme okugaya ukudla ngaphambi kokuba zimuncwe, noma azincibiliki kahle emathunjini ukuze zidlulele egazini ngobuningi obuwusizo. Lokhu kuyiqiniso ngisho nasezithakweni ezisungulwe kahle, ezifundwe kahle; isakhi ngokwaso singase sibe sihle, kodwa ifomethi esilethwa ngayo inganciphisa kakhulu ukuthi umzimba uthola malini ngempela.
Lokho I-Liposome Eyikho Ngempela
I-liposome isakhiwo esincane kakhulu, esiyindilinga esakhiwe ngama-phospholipid, uhlobo olufanayo lwama-molecule amafutha akha ulwelwesi lwawo wonke amaseli emzimbeni womuntu. Ngenxa yalokhu kufana kwesakhiwo, ama-liposome ngokuvamile abekezelelwa kahle uhlelo lokugaya ukudla futhi ayakwazi ukufaka isithako esisebenzayo ngaphakathi kwe-bilayer evikelayo. Lokhu kubalulekile ngezizathu ezimbili: igobolondo le-phospholipid lingavikela amakhemikhali azwelayo ekuwohlokeni njengoba edlula esiswini nasemathunjini, futhi ngenxa yokuthi igobolondo lifana nolwelwesi lweseli lwemvelo, lingasekela ukumuncwa okungcono odongeni lwamathumbu uma kuqhathaniswa nesithako esingavikelwe (Chen et al., 2024).
Ama-liposome nawo awavamile ngoba angathwala kokubili amakhemikhali ancibilika emanzini kanye nancibilika emafutheni ngaphakathi kwesakhiwo esifanayo, ama-molecule ancibilika emanzini enkabeni yamanzi, ama-molecule ancibilika emafutheni ngaphakathi kwe-lipid bilayer uqobo. Lokhu kuguquguquka kuyingxenye yesizathu sokuthi kungani ubuchwepheshe buhlolwe ezithakweni eziningi ezisebenzayo, kusukela kumavithamini namaminerali kuya ezikhiqizweni zezitshalo.
Lokho Ucwaningo Olukubonisayo
Ubufakazi obucacile bokulethwa kwe-liposomal buvame ukuvela ezifundweni ze-bioavailability ezivela ekhanda kuya ekhanda, ziqhathanisa uhlobo lwe-liposomal lwesithako ngokumelene nokulingana kwalo okujwayelekile, okungafakwanga i-capsulated. Kokunye ukuhlolwa okungahleliwe, okungaboni kabili, okulawulwa yi-placebo, ukwakheka kwe-liposomal vitamin C kukhiqize ukuhlushwa okuphezulu kwe-plasma okungu-27% kanye nokuhlushwa okuphezulu okungu-20% ngaphakathi kwama-leukocyte (uhlobo lweseli elimhlophe legazi elihambisana nokusebenza komzimba) uma kuqhathaniswa ne-vitamin C ejwayelekile, engeyona i-liposomal ngesilinganiso esifanayo (Purpura et al., 2024). Ngenxa yokuthi ama-leukocyte athembele ku-ascorbate emisebenzini yawo eminingana, lolu hlobo lokuthathwa kwezinga lamaseli lubhekwa njengophawu olubaluleke kakhulu kunamazinga e-plasma kuphela.
Kuhle ukucacisa ukuthi lobu bufakazi bubonisani nokuthi abubonisi ini. Ukuthuthukiswa kokutholakala kwe-bioavailability ngokuvamile kubikwe ngokwesithako ngasinye, ngokwesakhiwo ngasinye kunokuba kube yi-multiplier ehleliwe, yendawo yonke esebenza kunoma iyiphi i-compound esebenzayo efakwe ngaphakathi kwe-liposome. Ubukhulu benzuzo buxhomeke esithako esithile, usayizi kanye nokwakheka kwe-liposome, kanye nendlela ukwakheka okukhiqizwa futhi okuqiniswa ngayo.
I-LipoXbio™: Ipulatifomu Yokulethwa Yesayensi Ye-NaturMed
I-LipoXbio™ iyipulatifomu yokwakheka kwe-liposomal ye-NaturMed Scientific, eyenzelwe ukusebenzisa le sayensi yokulethwa kuyo yonke iphothifoliyo yezithako ebanzi yenkampani kunokuba iboshwe enkomponini eyodwa. I-LipoXbio™ ibhekana nayo ngokufaka i-capsulation kanye nokuvikela, inikeza abakhiqizi indlela ehlukile eya emgomweni ofanayo oyisisekelo: ukuthola isithako esisebenzayo lapho sidinga ukuya khona emzimbeni.
Empeleni, lokhu kusho ukuthi amafomula asekelwe ku-LipoXbio™ akhiwe ukuze:
- Vikela izinto ezibucayi kusukela ekuqhekekeni yi-asidi yesisu kanye nama-enzyme okugaya ukudla ngaphambi kokuba kungene.
- Sekela ukulethwa kwezithako ezincibilika emanzini namafutha, ukwandisa ububanzi bamakhemikhali ifomethi eyodwa yokulethwa engawamukela.
- Thuthukisa ukuzinza kokwakheka, okubalulekile ngezithako ezivame ukubola noma ukubola ngesikhathi sokuphelelwa yisikhathi.
- Nika amandla imithamo ephansi esebenzayo izithako lapho ukutholakala kwe-bioavailability okujwayelekile kuyisici esinqunyelwe, esingasekela ukwakheka okulula kube ama-capsule, impuphu, kanye nezakhiwo zoketshezi njengeziphuzo ezisebenzayo kanye nemijovo.
Umongo kanye nemikhawulo
Ukulethwa kwe-liposomal kuyindawo esungulwe kahle kakhulu yesayensi yezokwelapha kanye neyokudla, kodwa akusona isiqinisekiso semiphumela ethuthukisiwe yazo zonke izithako. Ezinye izinto ezisebenzayo sezivele zimuncwa kahle ngesimo sazo esijwayelekile futhi azizuzi okuningi ekufakweni kwe-capsulation, kuyilapho ezinye zidinga osayizi noma ukwakheka kwe-liposome ethile ukuze zibone inzuzo enenjongo. Ikhwalithi yokukhiqiza nayo ibaluleke kakhulu: i-liposome engakhekanga kahle noma engazinzile ingalahlekelwa yisakhiwo sayo sokuvikela ngaphambi kokufika emathunjini amancane, okunciphisa inzuzo yobuchwepheshe yalelo qembu. Njenganoma yiluphi ubuchwepheshe bokulethwa, icala lokuyisebenzisa liqine kakhulu uma ihlolwa isithako ngesithako, kunokuba kuthathwe njengokuthuthukiswa kwendawo yonke.
Qaphela: Izithako okuxoxwe ngazo kulesi sihloko ziyizithako zokudla, hhayi imikhiqizo yezokwelapha enelayisensi, futhi azihloselwe ukuxilonga, ukwelapha, ukwelapha, noma ukuvimbela noma yisiphi isifo. Abathengi abanezinkinga zempilo ezikhona noma labo abathatha imithi bayelulekwa ukuthi babonisane nochwepheshe wezempilo oqeqeshiwe ngaphambi kokusebenzisa.
Okubhekwayo
UChen, J., Hu, S., Sun, M., Shi, J., Zhang, H., Yu, H. kanye noYang, Z. (2024) 'Intuthuko yakamuva kanye nokuhumusha kwezokwelapha kwezinhlelo zokulethwa kwe-liposomal ekwelapheni umdlavuza', i-European Journal of Pharmaceutical Sciences , 193, isihloko 106688. Itholakala ku: https://doi.org/10.1016/j.ejps.2023.106688
I-Purpura, M., Jäger, R., Godavarthi, A., Bhaskarachar, D. kanye noTinsley, GM (2024) 'Ukulethwa kwe-liposomal kuthuthukisa ukumuncwa kwe-vitamin C ku-plasma kanye nama-leukocyte: ukuhlolwa okungaboni kabili, okulawulwa yi-placebo, okungahleliwe', i-European Journal of Nutrition , 63(8), amakhasi 3037–3046. Itholakala ku: https://doi.org/10.1007/s00394-024-03487-8
Isixwayiso: Lesi Sitatimende asikahlolwa yi-EFSA, i-KFDA noma i-FDA. Lo mkhiqizo awuhloselwe ukuxilonga, ukwelapha, ukwelapha, noma ukuvimbela noma yisiphi isifo. Nakuba ulwazi olunikeziwe lusekelwe ezinkombeni ezithembekile, asenzi noma yiziphi izimangalo noma iziqinisekiso ezithile. Kubalulekile ukubonisana nomeluleki wakho wezempilo ukuze uthole iseluleko nesiqondiso esiqondene nawe esiphathelene nempilo yakho.
