Izithako zezityalo ezinesiseko sobungqina esiqinileyo nesinamabakala amaninzi aziqhelekanga kudidi lolawulo lobunzima. I-Theolim, isithako esithathwe kwizityalo esikhethekileyo esaphuhliswa yi-NaturMed Scientific, sivavanywe kulandelelwano lophando lwangaphambi kweklinikhi nolweklinikhi. Eli nqaku lishwankathela oko ubungqina obupapashiweyo ngoku bukubonisayo, oko bungakubonisiyo, kunye nesizathu sokuba iprofayili yokhuseleko ibaluleke kubathengi.
Yintoni iTheolim?
I-Theolim yindibaniselwano esemgangathweni, enelungelo elilodwa lomenzi wezityalo ezimbini: ixolo leKey lime (Icitrus aurantifoliakunye nembewu yeCocoa (Ukhokho weTheobroma), zixutywe ngomlinganiselo we-2:1. Zombini ezi zinto zisisiseko kukutya okutyiwa kakhulu okunembali ende yokusetyenziswa ngabantu. Isithako esigqityiweyo silinganiswa ngokwemigangatho ephantsi ye-citric acid (5.0%), i-theobromine (0.5%), kunye ne-hesperidin (0.3%), kwaye iveliswa kwindawo eqinisekisiweyo yeGood Manufacturing Practice (Kundimi et al., 2024).
Le ndlela ikhethwe emva kwenkqubo yokuhlola ecwangcisiweyo apho kwavavanywa khona izicatshulwa zezityalo ezingaphezu kwe-1,000. Ukudibana kwezi zicatshulwa zimbini kwafunyaniswa ukuba kuvelisa iziphumo ezingaphezulu kunezo zombini izithako xa zodwa, uphawu olubizwa ngokuba yi-synergy kwi-pharmacology (Kundimi et al., 2024).
Inqanaba 1: Uphando lweeseli kunye nezilwanyana
Kwisifundo sobungqina bengcamango esapapashwa kwiJournal of the American Nutrition Association, uKundimi et al. (2024) baphande iTheolim kwiinkcubeko zeeseli zamafutha eempuku nakwimodeli yezilwanyana yokutyeba okubangelwa kukutya. Kwiiseli zamafutha, iTheolim yabonwa ukuba ixhasa ukuveliswa kwe-fibroblast growth factor-21 (FGF-21), iprotheyini yokubonisa i-metabolic ebandakanyeka kulawulo lwamandla, kunye nokuxhasa ukubonakaliswa kwe-uncoupling protein-1 (UCP-1) kunye ne-beta-3 adrenergic receptor (β3-AR), zombini iiprotheyini ezinxulumene nomsebenzi we-thermogenic kwizicubu zamafutha. Ezi ziphumo zabonwa kwinqanaba eliphezulu nge-extract edibeneyo kunakwisithako ngasinye kuphela (Kundimi et al., 2024).
Kwiimpuku ezityiwa ukutya okunamafutha amaninzi, ukongezwa ngomlomo kwiintsuku ezingama-28 kwakunxulunyaniswa nokunyuka okuxhomekeke kwidosi ekuchithweni kwamandla okuphumla kunye nokwehla kokunyuka kobunzima bomzimba kunye nobunzima bamafutha xa kuthelekiswa nezilwanyana ezingongezwanga. Ukutya akuhlukanga kakhulu phakathi kwamaqela ngeli xesha (Kundimi et al., 2024). Njengakuphando lonke lwezilwanyana, ezi ziphumo azinakusetyenziswa ngokuthe ngqo kwiziphumo zabantu kwaye ziqondwa ngcono njengobungqina bokuqala bokusebenza.
Inqanaba lesi-2: Uvavanyo oluQhelekileyo loMntu oluQhelekileyo
Uphononongo lokuqala lwabantu yayiluvavanyo oluqhutywa ngokungacwangciswanga, olungaboni kabini, olulawulwa yi-placebo olubandakanya abantu abadala abangama-60 abatyebe kakhulu abaneminyaka engama-20 ukuya kuma-39 ubudala (i-BMI engama-25 ukuya kuma-29.9 kg/m²), olupapashwe kwi-Food & Nutrition Research (Ammatalli et al., 2024). Abathathi-nxaxheba bafumana i-capsule enye ye-450 mg yeTheolim okanye i-placebo ehambelanayo, kwaye izinga lokuphumla kwe-metabolic (RMR) lilinganiswe kusetyenziswa i-calorimetry engathanga ngqo kwimizuzu engama-60, 120, kunye ne-180 emva kwedosi, kunye nangexesha nangemva kweseshoni yokuzilolonga okuphakathi ngosuku olulandelayo.
I-RMR kwiqela leTheolim yayiphezulu kakhulu ngokwezibalo kune-placebo kwimizuzu eli-120 kunye nemizuzu eli-180. I-oxidation yamafutha, isantya umzimba osebenzisa ngaso amafutha njengomthombo wamafutha, nayo yabonwa iphezulu kakhulu kwiqela leTheolim xa liphumle nakwimizuzu engama-20 emva kokuzilolonga, xa kuthelekiswa ne-placebo (Ammatalli et al., 2024).
Uxinzelelo lwegazi kunye nesantya sentliziyo azizange zahluke ngokubalulekileyo phakathi kwamaqela kuzo zombini ezi meko, kwaye onke amaxabiso ahlala ngaphakathi kumanqanaba aqhelekileyo e-physiological kuyo yonke indawo. Abathathi-nxaxheba kwiqela leTheolim nabo babhale amanqaku aphantsi kwimibuzo yokuphazamiseka kwemood eqinisekisiweyo ngexesha lokuzilolonga xa kuthelekiswa neqela le-placebo (Ammatalli et al., 2024). Akukho ziganeko zimbi zibikiweyo. Ababhali baqaphela ukuba olu yayiluphononongo lwexesha elifutshane, kwaye uphando lwexesha elide luya kufuneka ukuvavanya iziphumo eziqhubekayo.
Inqanaba lesi-3: Uvavanyo oluLawulwayo oluNgacwangciswanga lweeveki ezili-16
Ubungqina babantu obona bubalulekileyo ukuza kuthi ga ngoku buvela kuvavanyo olucwangcisiweyo, olungaboni kabini, olulawulwa yi-placebo, oluneendawo ezininzi kubantu abadala abali-120 abatyebe kakhulu abaneminyaka engama-25 ukuya kwengama-55 ubudala, olupapashwe kwi-Food & Nutrition Research (Chadalavada et al., 2025).
Abathathi-nxaxheba bafumana i-450 mg/ngosuku yeTheolim okanye i-placebo ehambelanayo kangangeeveki ezili-16, balandela ukutya kwabo okuqhelekileyo, baza bacelwa ukuba bahambe imizuzu engama-30 iintsuku ezintlanu ngeveki. Ubungakanani beekhalori ezithathwayo bujongiwe kuyo yonke indawo kwaye abuzange buhluke kakhulu phakathi kwamaqela.
Ubunzima bomzimba kunye nokwakheka kwawo: Emva kweeveki ezili-16, abantu abathathe iTheolim banciphise ubunzima babo ngokomndilili (malunga ne-4.25 kg) kunabo bathathe i-placebo (malunga ne-1 kg). Baye bancipha kakhulu kumafutha omzimba (malunga ne-4.28 kg xa kuthelekiswa ne-0.85 kg), kwaye i-BMI yabo yehla kakhulu. Ubunzima bemisipha buhlala bufana kakhulu, kunye nokwanda okuncinci kwiqela leTheolim kunye nokwehla okuncinci kwiqela le-placebo (Chadalavada et al., 2025).
Ukujikeleza kwesinqe nesinqe: Umjikelezo wesinqe wehliswe nge-avareji ye-4.32 cm kwiqela leTheolim xa kuthelekiswa ne-2.10 cm kwi-placebo, kunye nomjikelezo wesinqe nge-3.16 cm xa kuthelekiswa ne-1.31 cm ngokulandelelana, zombini ezi zinto zibalulekile ngokwezibalo xa kuthelekiswa ne-placebo kwiveki ye-16 (Chadalavada et al., 2025).
Izinga lokuphumla kwe-metabolism: Izinga le-metabolism lokuphumla linyuke ukusuka kwisiseko sangaphambi kokuthatha idosi nge-avareji ye-459 kcal/ngosuku kwiqela le-Theolim kwiveki ye-16, xa kuthelekiswa ne-102 kcal/ngosuku kwiqela le-placebo (p < 0.001 vs. placebo). Umlinganiselo wokutshintshiselana ngokuphefumla nawo wehlisiwe kakhulu kwiqela le-Theolim kwiveki yesi-8 neye-16, nto leyo enokubonisa ukunyuka okulinganiselweyo kokusetyenziswa kwamafutha njengomthombo wamandla, nangona utoliko lweklinikhi lwale ndlela yokulinganisa ngokwahlukileyo lulinganiselwe (Chadalavada et al., 2025).
Biomarkers: I-Serum GLP-1, i-hormone ebandakanyekayo ekulawuleni inkanuko kunye nomsebenzi we-metabolic, inyuke malunga ne-33% ukusuka kwisiseko kwiqela leTheolim kwiveki ye-16 (p < 0.001 vs. baseline; p < 0.05 vs. placebo). I-Serum adiponectin inyuke malunga ne-52% ukusuka kwisiseko, ngelixa i-ghrelin yehla kakhulu xa ithelekiswa nesiseko kunye ne-placebo.
Iprofayili ye-lipid kunye novakalelo lwe-insulin: I-cholesterol ye-LDL, umlinganiselo we-LDL/HDL, kunye ne-HOMA-IR, uphawu olusetyenziselwa ukuqikelela ukumelana ne-insulin, zonke zincitshiswe kakhulu kwiqela leTheolim kwiveki ye-16 xa kuthelekiswa ne-placebo (Chadalavada et al., 2025).
Ukubaluleka okubanzi kweklinikhi kwezi nguqu ze-biomarker kumxholo wesongezelelo sokutya kufuna uphando oluzimeleyo olongezelelekileyo.
Akukho ziganeko zimbi zibalulekileyo ezirekhodiweyo. Iziganeko ezincinci ezifana nentloko ebuhlungu, isicaphucaphu, kunye nokukhwehlela zazifana phakathi kwamaqela, kwaye zonke iiparameter ze-hematological kunye ne-biochemical zahlala ngaphakathi kumanqanaba aqhelekileyo kulo lonke ixesha (Chadalavada et al., 2025).
Uvavanyo loKhuseleko lwangaphambi konyango
Izifundo zokhuseleko zangaphambi konyango ezenziwe phantsi kwezikhokelo ze-OECD azifumananga bungqina bokuba kukho ubuthi okanye umonakalo wemfuza onxulumene neTheolim kwiidosi ezivavanyiweyo. Izifundo zezilwanyana ezisebenzisa idosi ephezulu kunye nexesha elide azizange zibike ziphumo zimbi okanye ukuphazamiseka okubalulekileyo kwiimpawu zempilo, ukusebenza kwamalungu omzimba, okanye ulwakhiwo lwezicubu (Kundimi et al., 2023).
Umxholo kunye nemida
Uvavanyo lweklinikhi lwenziwe eIndiya kwaye luxhaswe yinkampani ethile. Nangona lubhalisiwe kwaye lwapapashwa kwiijenali eziphononongwe ngoontanga ngokulandela izikhokelo zeGood Clinical Practice, ukuphindaphinda ngokuzimeleyo kubemi baseYurophu kuya kongeza ukuzithemba kwiziphumo. Uvavanyo lubhalise abantu abadala abatyebileyo abane-BMIs phakathi kwama-25 nama-29.9 kg/m², kwaye iziphumo zisenokungasebenzi kubantu abangaphandle kolu luhlu okanye abaneengxaki zempilo ezibalulekileyo. Iziphumo zibonwe kunye nokutya okuqhelekileyo kunye nenkqubo yokuhamba kancinci (Chadalavada et al., 2025).
Phawula: I-Theolim sisithako sokongezelela ukutya, asiyomveliso yezonyango enelayisenisi, kwaye ayenzelwanga ukuxilonga, ukunyanga, ukunyanga, okanye ukuthintela nasiphi na isifo. Abathengi abaneengxaki zempilo esele zikhona okanye abo bathatha amayeza bayacetyiswa ukuba badibane neengcali zempilo ezifanelekileyo ngaphambi kokuba basebenzise.
Ucaphulo
Ammatalli, NKR, Kuricheti, SSSK, Veeramachaneni, S., Koo, YK, Ramanathan, G. kunye noYalamanchi, A. (2024) 'Indibaniselwano ye Icitrus aurantifolia ixolo leziqhamo kunye Ukhokho weTheobroma ukongezwa kwezicatshulwa zembewu kuphucula amazinga e-metabolic kubantu abatyebe kakhulu: uphando olucwangcisiweyo, olulawulwa yi-placebo, oluxutyiweyo, UPhando lokutya kunye neSondlo, 68, inqaku 10745. Ifumaneka apha: https://doi.org/10.29219/fnr.v68.10745
Chadalavada, A., Koo, YK, Kim, S., Veeramachaneni, S., Ramanathan, G. kunye neYalamanchi, A. (2025) 'Ukwakheka kwebhotani ye-thermogenic equlathe Icitrus aurantifolia ixolo leziqhamo kunye Ukhokho weTheobroma izicatshulwa zembewu ziphucula ukwakheka komzimba kubantu abadala abatyebileyo: uphando lweklinikhi', UPhando lokutya kunye neSondlo, 69, inqaku 12159. Ifumaneka apha: https://doi.org/10.29219/fnr.v69.12159
I-Kundimi, S., Chinta, G., Alluri, KV, Golakoti, T., Veeramachaneni, S., Ramanathan, G. kunye neSengupta, K. (2023) 'Uvavanyo lokhuseleko lwangaphambili lwe-LN19183: acute, subchronic, dermal, ocular kunye ne-genotoxicity studies', Izifundo ze-Nutrascript ze-Nutradutical ezingenayo ne-genotoxicity IVijayawada, eIndiya.
Kundimi, S., Chinta, G., Alluri, KV, Golakoti, T., Veeramachaneni, S., Ramanathan, G. kunye noSengupta, K. (2024) 'Ulwakhiwo lwezityalo oluhambelanayo lunyusa iindleko zamandla okuphumla kwaye lunciphisa ukutyeba kwiimpuku ezinamafutha amaninzi ezitya ukutya', Ijenali ye-American Nutrition Association, 43(3), iphe. 286–295. Ifumaneka apha: https://doi.org/10.1080/27697061.2023.2280777
hlobo: Ingxelo ayikhange ihlolwe yi-EFSA, i-KFDA okanye i-FDA. Le mveliso ayenzelwanga ukuxilonga, ukunyanga, ukunyanga, okanye ukuthintela nasiphi na isifo. Nangona ulwazi olunikiweyo lusekelwe kwiingxelo ezithembekileyo, asenzi naziphi na izibango okanye iziqinisekiso ezithile. Kubalulekile ukubonisana nomcebisi wakho wezempilo ukuze ufumane iingcebiso kunye nesikhokelo esihambelana nempilo yakho.
