I-Nattokinase yi-enzyme yendalo ephuma kwi-natto, ukutya kwendabuko kwaseJapan okwenziwe ngokubilisa iisoya nge-Bacillus subtilis natto. Ifumene umdla kwezesayensi ngenxa yendima yayo enokuba nayo ekuxhaseni impilo-ntle yentliziyo, ukuhamba kwegazi okunempilo, kunye nokujikeleza kwegazi okuqhelekileyo. I-Nattokinase yaziwa kakhulu ngomsebenzi wayo we-fibrinolytic, oko kuthetha ukuba inokunceda ukuxhasa inkqubo yendalo yomzimba yokuqhekeza i-fibrin, iproteni ebandakanyeka ekwakhiweni kwamahlwili egazi.
Ngokungafaniyo nezinye izithako ezininzi zezityalo, i-nattokinase sisithako esisebenzayo esisekelwe kwi-enzyme. Ifundwe ngeziphumo zayo ezinokubakho kuxinzelelo lwegazi, ukuxinana kwegazi, iimpawu ezinxulumene nokugabha kwegazi, imetabolism yamafutha, kunye nempilo yemithambo yegazi. Nangona kunjalo, ubungqina obukhoyo busaphuhliswa, kwaye iziphumo ziyahluka ngokuxhomekeke kumthamo, uyilo lophando, inani labantu, kunye nobude bexesha. Ngezantsi kukho iingenelo ezininzi zempilo ze-nattokinase ngokusekelwe kuphando lwesayensi.
1. Ixhasa ukuhamba kwegazi okunempilo kunye nomsebenzi we-Fibrinolytic
I-Nattokinase inokuxhasa ukujikeleza kwegazi okunempilo ngokunceda umzimba ugcine ulungelelwano oluqhelekileyo lwe-fibrin kunye neendlela zendalo zokwaphuka kwamahlwili.
Kuphononongo olunesihloko esithi Nattokinase: I-Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease, abaphandi bachaze i-nattokinase njenge-enzyme ye-fibrinolytic eneempawu ezinokubangela ukuxhasa intliziyo. Olu phononongo luchaza ukuba i-nattokinase inokunceda ukuqhekeza i-fibrin ngokuthe ngqo kwaye inokuxhasa inkqubo yomzimba ye-fibrinolytic ngokuchaphazela i-plasmin kunye nezinye iindlela ezinxulumene ne-clot. Ezi ndlela zibonisa ukuba i-nattokinase inokudlala indima ekuxhaseni ukuhamba kwegazi okunempilo kunye nokusebenza kwemithambo yegazi (Weng et al., 2017).
Olunye uphononongo, iNattokinase: Indlela Ethembisayo Yokuthintela Nonyango Lwezifo Zentliziyo, luxoxe nge-nattokinase njengenye yezona zinto zisebenzayo ze-natto. Ababhali bagxininise iziphumo zayo ezinokubakho kwi-fibrinolysis, uxinzelelo lwegazi, i-lipid metabolism, kunye neempawu ezinxulumene ne-atherosclerosis. Nangona kunjalo, baqaphele ukuba kufuneka uphando oluninzi lwabantu ukuqinisekisa ukubaluleka kwayo kwezonyango, idosi efanelekileyo, kunye nokhuseleko lwexesha elide kumaqela ahlukeneyo (Chen et al., 2018).
2. Inganceda Ukugcina Uxinzelelo Lwegazi Olusempilweni
I-Nattokinase iye yafundwa ngendima yayo enokuba nayo ekuxhaseni uxinzelelo lwegazi oluqhelekileyo, ingakumbi kubantu abanezinga eliphezulu loxinzelelo lwegazi.
Kwisifundo esenziwe ngokungacwangciswanga, esingaboni kabini, nesilawulwa yi-placebo, abaphandi bafunde abantu abadala abangama-86 abaneminyaka engama-20 ukuya kuma-80 ubudala abanoxinzelelo lwegazi lwe-systolic olunganyangwanga phakathi kwe-130 kunye ne-159 mmHg. Abathathi-nxaxheba bafumana i-nattokinase kwi-2,000 FU ngosuku okanye i-placebo kangangeeveki ezi-8. Abathathi-nxaxheba abangama-73 bagqibe uphando. Xa kuthelekiswa ne-placebo, i-nattokinase yayinxulunyaniswa nokwehla koxinzelelo lwegazi lwe-systolic kunye ne-diastolic, kunye notshintsho olupheleleyo olumalunga ne--5.55 mmHg kunye ne--2.84 mmHg, ngokulandelelana. Olu phononongo lukwabone ukwehla komsebenzi we-plasma renin, nto leyo ebonisa indlela enokwenzeka enxulumene nokulawulwa koxinzelelo lwegazi (UKim et al., 2008).
Kolunye uphando lwaseMntla Melika olulawulwa yi-placebo, olungenamkhethe, olungaboni kabini, olulawulwa yi-placebo, abathathi-nxaxheba abangama-79 abanoxinzelelo lwegazi oluphezulu batya i-100 mg ye-nattokinase imihla ngemihla okanye i-placebo kangangeeveki ezi-8. Olu phononongo luhlolisise uxinzelelo lwegazi kunye neempawu ezinxulumene nomngcipheko wentliziyo, kuquka ne-von Willebrand factor. Iziphumo zibonise ukuba ukusetyenziswa kwe-nattokinase kunxulunyaniswa nokuncipha koxinzelelo lwegazi kunye nokwehla kwe-von Willebrand factor, uphawu olunxulunyaniswa nempilo yemithambo yegazi kunye nomsebenzi wokugalela igazi (Jensen et al., 2016).
Ezi zifundo zibonisa ukuba i-nattokinase inokuxhasa ukulinganisela koxinzelelo lwegazi kumaqela athile. Nangona kunjalo, akufanele ithathwe njengendawo yokuthatha indawo yamayeza amiselweyo okulwa noxinzelelo lwegazi okanye unyango.
3. Ingaxhasa ibhalansi yoMngcipheko weNtliziyo neMithambo
I-Nattokinase inokunceda ukuxhasa impilo-ntle yentliziyo ngokuchaphazela iimpawu ezithile ezinxulumene nokugabha kwegazi, ukusebenza kwemithambo yegazi, kunye nokujikeleza kwegazi.
Uphononongo lukaJensen et al. (2016) lubaluleke kakhulu kuba aluzange luhlolisise uxinzelelo lwegazi kuphela kodwa lukwalinganise ne-von Willebrand factor kunye ne-platelet factor-4. I-Von Willebrand factor ibandakanyeka ekunamatheleni kwe-platelet kunye nokwakheka kwe-clot. Ukunciphisa olu phawu kunokubonisa impembelelo exhasayo kwi-vascular kunye ne-circulatory balance. Nangona kunjalo, oku akuthethi ukuba i-nattokinase ithintela iziganeko zentliziyo, njengoko kufuneka uvavanyo olukhulu nolude lweklinikhi ukuqinisekisa iziphumo ezinjalo (Jensen et al., 2016).
Uphononongo olucwangcisiweyo luka-2023 kunye nohlalutyo lwe-meta olunesihloko esithi Nattokinase Supplementation kunye neCardiovascular Risk Factors luvavanye izilingo ezilawulwa ngokungacwangciswanga kwi-nattokinase kunye neempawu zentliziyo. Uphononongo lufumanise ukuba ukongezwa kwe-nattokinase kunxulunyaniswa nokunciphisa okuncinci kuxinzelelo lwegazi lwe-systolic kunye ne-diastolic. Nangona kunjalo, ababhali baqaphele ukuba ubungqina bezinye iimpawu, kubandakanya iziphumo ze-lipid kunye ne-coagulation, bebungaguquki kangako kwizifundo (Li et al., 2023).
Lilonke, i-nattokinase inokuxhasa iimpawu zentliziyo ezikhethiweyo, kodwa iziphumo zayo zibonakala zixhomekeke kuluntu olufunyenweyo, idosi, ukulungelelaniswa kwemveliso, kunye nobude bokusetyenziswa.
4. Inganceda ukuxhasa i-Lipid Metabolism kunye neMpilo yeArterial
Ezinye izifundo zibonisa ukuba i-nattokinase inokuxhasa imetabolism yamafutha kunye nempilo yemithambo yegazi, kodwa ubungqina abuhambelani ngokupheleleyo.
Kwisifundo seklinikhi malunga ne-atherosclerosis yemithambo ye-carotid kunye ne-hyperlipidemia, ukongeza i-nattokinase kuphandwe ngempembelelo yayo kubukhulu be-carotid intima-media, ubungakanani be-plaque, kunye neprofayili ye-lipid. Iziphumo zibonise ukuba i-nattokinase inokunciphisa ukulinganiswa kwe-plaque kwaye iphucule iimpawu ezithile ze-lipid kubathathi-nxaxheba abane-atherosclerosis kunye ne-lipids eziphezulu (Ren et al., 2017).
Uphononongo olulandelayo luhlolisise idosi ephezulu yemihla ngemihla ye-nattokinase, i-10,800 FU ngosuku, ngokunxulumene nokuqhubela phambili kwe-atherosclerosis kunye ne-hyperlipidemia. Abaphandi baxele ukuba le dosi inxulunyaniswa nophuculo kwiprofayili ye-lipid kunye nemilinganiselo enxulumene ne-atherosclerosis. Nangona kunjalo, iziphumo zedosi ephezulu akufuneki zihlanganiswe kuzo zonke iimveliso ze-nattokinase okanye iidosi zesongezelelo ezisemgangathweni ngaphandle kovavanyo olucokisekileyo (Chen et al., 2022).
Kwangaxeshanye, ayizizo zonke izifundo ezibonise iziphumo ezilungileyo. I-Nattokinase Atherothrombotic Prevention Study, uvavanyo olulawulwa ngokungacwangciswanga kubantu abasempilweni abasengozini ephantsi yentliziyo, ifumanise ukuba ukongezwa kwe-nattokinase akuzange kuyichaphazele kakhulu inkqubela phambili ye-atherosclerosis engaphantsi kweklinikhi, uxinzelelo lwegazi, okanye iimpawu zelebhu emva kwexesha eliphakathi lonyango lweminyaka emi-3 (UHodis nabanye, 2021).
Lo mahluko ubonisa ukuba i-nattokinase inokuba luncedo ngakumbi kumaqela athile abantu, ingakumbi abo baneengozi ezithile zentliziyo, kunokuba ibe ngabantu abasempilweni abasengozini encinci.
5. Inganikezela ngenkxaso njengenxalenye yendlela yokuphila kakuhle kwentliziyo
Ngamanye amaxesha iNattokinase ifundwa kunye nezinye izithako ezisebenzayo, ingakumbi kuphando lwempilo ye-cardiometabolic.
Kwilingo lovavanyo olucwangcisiweyo ngo-2024, olungaboni kabini, olulawulwa yi-placebo, abaphandi bafunde i-nattokinase edityaniswe nerayisi yemvubelo ebomvu kwizigulane ezinesifo semithambo yentliziyo esizinzileyo. Olu phononongo luhlolisise iziphumo zokunciphisa amafutha emzimbeni, ukunciphisa uxinzelelo lwegazi, kunye ne-antithrombotic. Iziphumo zibonise ukuba indibaniselwano inokuphucula iiparameter ezithile ze-cardiometabolic, nangona kubalulekile ukuqaphela ukuba olu yayiluphononongo oludibeneyo. Ke ngoko, iingenelo azinakubalelwa kwi-nattokinase yodwa (Liu et al., 2024).
Olu hlobo lophando lubalulekile kuba impilo yentliziyo nemithambo yegazi ichaphazeleka zizinto ezininzi, kubandakanya ukutya, umsebenzi womzimba, amanqanaba e-lipid, uxinzelelo lwegazi, ukudumba, uxinzelelo lwe-oxidative, kunye ne-genetics. I-Nattokinase ingangena kwisicwangciso esibanzi sempilo-ntle, kodwa kufuneka ibekwe njengesithako esixhasayo endaweni yesisombululo esizimeleyo.
6. Ngokubanzi Inyamezelwa Kakuhle, Kodwa Kufuneka Unonophelo
Kubonakala ngathi iNattokinase iyanyamezela kwizifundo ezininzi zabantu, kodwa ifuna ukusetyenziswa ngendlela efanelekileyo ngenxa yempembelelo yayo enokubakho kwiindlela zokujiya kwegazi.
Uphononongo lweklinikhi lokwenyani luvavanye i-nattokinase kwi-100 mg ngosuku kwizigulana ezivunyelwe utyando lwemithambo yegazi. Abaphandi baxele ukuba kukho ukubonwa okuxhasa ukhuseleko lokusetyenziswa kwe-nattokinase kule meko, nangona ulwalathiso lomntu ngamnye lubalulekile, ingakumbi kubantu abasebenzisa amayeza okunciphisa igazi okanye amayeza okunciphisa iiplatelet (UGallelli nabanye, 2021).
Ekubeni i-nattokinase inokuba nefuthe kwi-fibrinolysis kunye neempawu ezinxulumene nokuqhekeka kwegazi, isenokungafaneleki kuye wonke umntu. Abantu abasebenzisa amayeza okunciphisa igazi, i-aspirin, amayeza okunciphisa ukugabha kwegazi, okanye amayeza okunciphisa iiplatelet, kunye nabo baneengxaki zokopha, utyando oluzayo, ukukhulelwa, okanye iimeko zempilo ezinzulu, kufuneka bafune iingcebiso zonyango ngaphambi kokusebenzisa i-nattokinase.
I-Nattokinase yi-enzyme eyahlukileyo ephuma kwiimbotyi zesoya ezibilisiweyo kwaye yaziwa kakhulu ngendima yayo enokuba nayo ekuxhaseni impilo yentliziyo kunye neyokujikeleza kwegazi. Iindawo zayo ezinzulu zophando ziquka:
- Inkxaso yokuhamba kwegazi okunempilo
- Umsebenzi we-Fibrinolytic
- Ibhalansi yoxinzelelo lwegazi
- Inkxaso yophawu lwemithambo yegazi
- I-metabolism ye-lipid kunye nempilo yemithambo yegazi kubantu abakhethiweyo
Uphando olufumanekayo luthembisa, kodwa aluhambelani ngokupheleleyo. Ezinye izifundo zibonisa uphuculo olubalulekileyo kuxinzelelo lwegazi, umsebenzi we-fibrinolytic, kunye neempawu zentliziyo, ngelixa ezinye zibonisa impembelelo encinci okanye engenamsebenzi, ingakumbi kubantu abasempilweni abasengozini encinci. Oku kuthetha ukuba i-nattokinase inokusebenza ngokwahlukileyo ngokuxhomekeke kwimeko yempilo yomntu ngamnye, idosi, ubude bexesha, kunye nomgangatho wemveliso.
I-Nattokinase ifanele ibonwe njengesithako esisebenzayo esixhasayo endaweni yonyango okanye unyango. Xa isetyenziswa ngokufanelekileyo, inokuba longezo oluxabisekileyo kwimixube yempilo yentliziyo, ingakumbi leyo igxile ekujikelezeni kwegazi, ukwaluphala okunempilo, kunye nokulinganisela kwemetabolism.
hlobo: Le ngxelo ayikavavanywa yi-EFSA, i-KFDA okanye i-FDA. Le mveliso ayenzelwanga ukuxilonga, ukunyanga, ukunyanga, okanye ukuthintela nasiphi na isifo. Nangona ulwazi olunikiweyo lusekelwe kwiingxelo ezithembekileyo, asenzi naziphi na izibango okanye iziqinisekiso ezithile. Kubalulekile ukubonisana nomcebisi wakho wezempilo ukuze ufumane iingcebiso kunye nesikhokelo esihambelana nempilo yakho.
Ucaphulo
- UChen, H., McGowan, EM, Ren, N., Lal, S., Nassif, N., Shad-Kaneez, F., Qu, X. kunye noLin, Y., 2018. I-Nattokinase: Enye indlela ethembisayo yokuthintela nokunyanga izifo zentliziyo. Biomarker Insights, 13, iphepha 1-8.
- U-Chen, H., McGowan, EM, Ren, N., Lal, S., Nassif, N., Shad-Kaneez, F., Qu, X. kunye noLin, Y., 2022. Ulawulo olusebenzayo lwenkqubela phambili ye-atherosclerosis kunye ne-hyperlipidemia kunye ne-nattokinase. Imida kwiCardiovascular Medicine.
- Gallelli, G., Cione, E., Caroleo, MC, Carullo, G., Genchi, G., Rende, P. kunye noCitraro, R., 2021. Idatha ebhalwe ebomini bokwenyani ixhasa ukhuseleko lwe-nattokinase kwizigulana ezinezifo zemithambo yegazi. Amanzi, 13 (6), iphe. 2031.
- UHodis, HN, Mack, WJ, Dustin, L., Mahrer, PR kunye no-Azen, SP, 2021. Uphononongo lokuthintela i-Nattokinase atherothrombotic: Uvavanyo olulawulwa ngokungacwangciswanga. I-Clinical Hemorheology kunye ne-Microcirculation, 78(4), iphe. 339–353.
- UJensen, GS, uLenninger, M., uEro, MP kunye noBenson, KF, 2016. Ukusetyenziswa kwe-nattokinase kunxulunyaniswa noxinzelelo lwegazi oluphantsi kunye ne-von Willebrand factor, uphawu lomngcipheko wentliziyo: Iziphumo ezivela kuvavanyo lweklinikhi lwaseMntla Melika olucwangcisiweyo, olungaboni kabini, olulawulwa yi-placebo, oluneziko ezininzi. Ulawulo oluHlanganisiweyo loxinzelelo lwegazi, 9, iphepha 95-104.
- UKim, JY, Gum, SN, Paik, JK, Lim, HH, Kim, KC, Ogasawara, K., Inoue, K., Park, S., Jang, Y. kunye noLee, JH, 2008. Iziphumo ze-nattokinase kuxinzelelo lwegazi: Uvavanyo olulawulwayo nolungacwangciswanga. Uphando loxinzelelo lwegazi, 31(8), iphe. 1583–1588.
- ULi, X., uZheng, X., uLiu, Y. kunye noZhang, Y., 2023. Ukongezwa kweNattokinase kunye nezinto ezinobungozi bentliziyo: Uphononongo olucwangcisiweyo kunye nohlalutyo lwe-meta. Uphononongo kwi-Cardiovascular Medicine, 24 (8), iphe. 234.
- Liu, M., Zhang, H., Wang, Y., Li, X. kunye noChen, J., 2024. Iziphumo ze-nattokinase zokunciphisa amafutha, ukunciphisa uxinzelelo lwegazi, kunye ne-antithrombotic ezidityaniswe nerayisi yemvubelo ebomvu kwizigulane ezinesifo semithambo yentliziyo esizinzileyo: Uvavanyo olulawulwa yi-placebo olungacwangciswanga, olungaboni kabini. Imida kwiZondlo.
- URen, NN, Chen, HJ, Li, Y., McGowan, E. kunye noLin, YG, 2017. Uphononongo lweklinikhi malunga nefuthe le-nattokinase kwi-carotid artery atherosclerosis kunye ne-hyperlipidaemia. Zhonghua Yi Xue Za Zhi, 97(26), iphe. 2038–2042.
- UWeng, Y., UYao, J., USparks, S. kunye noWang, KY, 2017. I-Nattokinase: I-arhente yomlomo yokulwa noxinzelelo lwegazi yokuthintela isifo sentliziyo. I-International Journal ye-Molecular Sciences, 18 (3), iphe. 523.
