Nattokinase ke enzyme ea tlhaho e ntšoang ho natto, lijo tsa setso tsa Majapane tse entsoeng ka ho belisa soya ka Bacillus subtilis natto. E fumane thahasello ea saense ka lebaka la karolo ea eona e ka bang teng ho tšehetseng bophelo bo botle ba pelo le methapo ea mali, phallo e ntle ea mali le phallo e tloaelehileng ea mali. Nattokinase e tsebahala haholo ka ts'ebetso ea eona ea fibrinolytic, ho bolelang hore e ka thusa ho tšehetsa ts'ebetso ea tlhaho ea 'mele ea ho qhaqha fibrin, protheine e amehang ho thehoeng ha maqeba a mali.
Ho fapana le metsoako e mengata ea limela, nattokinase ke motsoako o sebetsang o thehiloeng ho enzyme. E ithutiloe bakeng sa litlamorao tsa eona tse ka bang teng khatellong ea mali, ho teteana ha mali, matšoao a amanang le ho ruruha ha mali, metabolism ea lipid le bophelo bo botle ba methapo ea mali. Leha ho le joalo, bopaki bo fumanehang bo ntse bo hola, 'me liphetho li fapana ho latela tekanyo, moralo oa thuto, palo ea batho le nako. Ka tlase ke melemo e 'maloa ea bophelo bo botle ea nattokinase e thehiloeng lipatlisisong tsa saense.
1. E tšehetsa Phallo ea Mali e Phetseng Hantle le Mosebetsi oa Fibrinolytic
Nattokinase e ka tšehetsa phallo ea mali e phetseng hantle ka ho thusa 'mele ho boloka botsitso bo tloaelehileng ba fibrin le mekhoa ea tlhaho ea ho pshatla maqeba a mali.
Tlhahlobong e nang le sehlooho se reng Nattokinase: Moemeli oa Molomo oa Thibelo ea Lefu la Pelo le Methapo, bafuputsi ba hlalositse nattokinase e le enzyme ea fibrinolytic e nang le litšobotsi tse ka tšehetsang pelo le methapo ea mali. Tlhahlobo e hlalosa hore nattokinase e ka thusa ho qhaqha fibrin ka kotloloho 'me e ka boela ea tšehetsa tsamaiso ea fibrinolytic ea' mele ka ho susumetsa plasmin le litsela tse ling tse amanang le ho bola ha mali. Mekhoa ena e bontša hore nattokinase e ka bapala karolo ho ts'ehetsa phallo ea mali e phetseng hantle le ts'ebetso ea methapo ea mali (Weng et al., 2017).
Tlhahlobo e 'ngoe, Nattokinase: Mokhoa o Tšepisang oa Thibelo le Kalafo ea Mafu a Pelo, e buile ka nattokinase e le e 'ngoe ea likarolo tse sebetsang ka ho fetisisa tsa natto. Bangoli ba totobalitse litlamorao tsa eona tse ka bang teng ho fibrinolysis, khatello ea mali, metabolism ea lipid, le matšoao a amanang le atherosclerosis. Leha ho le joalo, ba boetse ba hlokometse hore ho hlokahala lithuto tse ling tsa batho ho netefatsa bohlokoa ba eona ba bongaka, tekanyo e loketseng, le polokeho ea nako e telele ho baahi ba fapaneng (Chen le al., 2018).
2. E ka Thusa ho Boloka Khatello ea Mali e Phetse Hantle
Nattokinase e ithutiloe ka lebaka la karolo ea eona e ka bang teng ho tšehetseng khatello e tloaelehileng ea mali, haholo-holo ho batho ba nang le maemo a phahameng a khatello ea mali.
Tekong e sa reroang, e sa boneng habeli, e laoloang ke placebo, bafuputsi ba ithutile batho ba baholo ba 86 ba lilemo li 20 ho isa ho tse 80 ba nang le khatello ea mali ea systolic e sa phekoloang e pakeng tsa 130 le 159 mmHg. Barupeluoa ba ile ba fumana nattokinase ho 2,000 FU ka letsatsi kapa placebo ka libeke tse 8. Barupeluoa ba 73 ba qetile thuto. Ha e bapisoa le placebo, nattokinase e ne e amahanngoa le phokotso ea khatello ea mali ea systolic le diastolic, ka liphetoho tse ka bang -5.55 mmHg le -2.84 mmHg, ka ho latellana. Phuputso e boetse e bone phokotso ea ts'ebetso ea renin ea plasma, e bontšang mokhoa o ka bang teng o amanang le taolo ea khatello ea mali (Kim et al., 2008).
Phuputsong e 'ngoe e sa reroang, e sa boneng habeli, e laoloang ke placebo Amerika Leboea, barupeluoa ba 79 ba nang le khatello e phahameng ea mali ba ile ba ja nattokinase ea 100 mg letsatsi le letsatsi kapa placebo ka libeke tse 8. Phuputso e hlahlobile khatello ea mali le matšoao a amanang le kotsi ea pelo le methapo ea mali, ho kenyeletsoa le von Willebrand factor. Liphuputso li bontšitse hore tšebeliso ea nattokinase e ne e amahanngoa le khatello e fokotsehileng ea mali le phokotso ea von Willebrand factor, letšoao le amanang le bophelo bo botle ba methapo ea mali le ts'ebetso ea ho hoama ha mali (Jensen et al., 2016).
Lithuto tsena li bontša hore nattokinase e ka tšehetsa ho leka-lekana ha khatello ea mali lihlopheng tse itseng. Leha ho le joalo, ha ea lokela ho nkoa e le sebaka sa meriana e laetsoeng ea ho fokotsa khatello ea mali kapa tlhokomelo ea bongaka.
3. E ka 'na ea Tšehetsa Tekanyo ea Letšoao la Kotsi ea Pelo le Methapo
Nattokinase e ka thusa ho tšehetsa bophelo bo botle ba pelo le methapo ea mali ka ho susumetsa matšoao a khethiloeng a amanang le ho hoama ha mali, ts'ebetso ea methapo ea mali le phallo ea mali.
Phuputso ea Jensen et al. (2016) e bohlokoa haholo hobane ha ea ka ea hlahloba khatello ea mali feela empa hape e ile ea lekanya von Willebrand factor le platelet factor-4. Von Willebrand factor e ameha ho khomareleng ha platelet le ho thehoa ha clot. Phokotso ea letšoao lena e ka fana ka maikutlo a phello e tšehetsang ho leka-lekana ha methapo ea mali le potoloho ea mali. Leha ho le joalo, sena ha se bolele hore nattokinase e thibela liketsahalo tsa pelo le methapo ea mali, kaha liteko tse kholo le tse telele tsa kliniki lia hlokahala ho netefatsa liphetho tse joalo (Jensen et al., 2016).
Tlhahlobo e hlophisitsoeng ea 2023 le tlhahlobo ea meta e nang le sehlooho se reng Nattokinase Supplementation le Cardiovascular Risk Factors li hlahlobile liteko tse laoloang ka mokhoa o sa reroang ho nattokinase le matšoao a pelo le methapo ea mali. Tlhahlobo e fumane hore tlatsetso ea nattokinase e ne e amahanngoa le phokotso e nyane khatellong ea mali ea systolic le diastolic. Leha ho le joalo, bangoli ba boetse ba hlokometse hore bopaki ba matšoao a mang, ho kenyeletsoa le liphetho tsa lipid le coagulation, bo ne bo sa tsitsane ho pholletsa le lithuto (Li et al., 2023).
Ka kakaretso, nattokinase e ka tšehetsa matšoao a khethiloeng a pelo le methapo ea mali, empa liphello tsa eona li bonahala li itšetlehile ka palo ea batho ba ithutoang, tekanyo, tekanyetso ea sehlahisoa, le nako ea tšebeliso.
4. E ka Thusa ho Tšehetsa Metabolism ea Lipid le Bophelo bo Botle ba Methapo
Lithuto tse ling li bontša hore nattokinase e ka tšehetsa metabolism ea lipid le bophelo bo botle ba methapo ea mali, empa bopaki ha bo lumellane ka botlalo.
Phuputsong ea bongaka mabapi le atherosclerosis ea methapo ea carotid le hyperlipidemia, ho ile ha hlahlojoa nattokinase supplementation bakeng sa phello ea eona holim'a botenya ba carotid intima-media, boholo ba plaque, le boemo ba lipid. Liphuputso li bontšitse hore nattokinase e ka fokotsa litekanyo tse amanang le plaque le ho ntlafatsa matšoao a itseng a lipid ho barupeluoa ba nang le atherosclerosis le lipids tse phahameng (Ren et al., 2017).
Phuputso e 'ngoe hamorao e ile ea hlahloba tekanyo e phahameng ea letsatsi le letsatsi ea nattokinase, 10,800 FU ka letsatsi, mabapi le tsoelo-pele ea atherosclerosis le hyperlipidemia. Bafuputsi ba tlalehile hore tekanyo ena e ne e amahanngoa le ntlafatso ea boemo ba lipid le litekanyo tse amanang le atherosclerosis. Leha ho le joalo, liphuputso tsa tekanyo e phahameng ha lia lokela ho akaretsoa lihlahisoa tsohle tsa nattokinase kapa litekanyetso tse tloaelehileng tsa tlatsetso ntle le tlhahlobo e hlokolosi (Chen le al., 2022).
Ka nako e ts'oanang, ha se lithuto tsohle tse bontšitseng liphetho tse ntle. Thuto ea Nattokinase Atherothrombotic Prevention Study, teko e laoloang ka mokhoa o sa reroang ho batho ba phetseng hantle ba nang le kotsi e tlase ea pelo le methapo ea mali, e fumane hore tlatsetso ea nattokinase ha ea ka ea ama haholo tsoelo-pele ea atherosclerosis e ka tlase ho kliniki, khatello ea mali, kapa matšoao a laboratori kamora nako e mahareng ea kalafo ea lilemo tse 3 (Hodis le ba bang, 2021).
Phapang ena e bontša hore nattokinase e ka ba ea bohlokoa haholo ho batho ba khethiloeng, haholo-holo ba nang le mabaka a itseng a kotsi ea pelo le methapo ea mali, ho fapana le batho ba phetseng hantle ba nang le kotsi e tlase.
5. E ka fana ka Tšehetso e le Karolo ea Mokhoa oa Boiketlo ba Cardiometabolic
Ka linako tse ling Nattokinase e ithutoa hammoho le metsoako e meng e sebetsang, haholo-holo lipatlisisong tsa bophelo bo botle ba pelo le metabolism.
Tekong e entsoeng ka mokhoa o sa reroang, o foufetseng habeli, o laoloang ke placebo ka 2024, bafuputsi ba ithutile nattokinase e kopantsoeng le raese e khubelu ea tomoso ho bakuli ba nang le lefu le tsitsitseng la methapo ea pelo. Phuputso e hlahlobile litlamorao tsa ho theola mafura, ho fokotsa khatello ea mali le ho fokotsa ho ruruha ha methapo ea mali. Liphetho li bontšitse hore motsoako o ka ntlafatsa likarolo tse itseng tsa cardiometabolic, leha ho le bohlokoa ho hlokomela hore ena e ne e le thuto e kopaneng. Ka hona, melemo e ke ke ea amahanngoa le nattokinase feela (Liu et al., 2024).
Mofuta ona oa lipatlisiso o bohlokoa hobane bophelo bo botle ba pelo le methapo bo susumetsoa ke lintlha tse ngata, ho kenyeletsoa lijo, boikoetliso ba 'mele, maemo a mafura, khatello ea mali, ho ruruha, khatello ea oxidative le liphatsa tsa lefutso. Nattokinase e ka 'na ea kena leano le pharaletseng la bophelo bo botle, empa e lokela ho beoa e le motsoako o tšehetsang ho e-na le tharollo e ikemetseng.
6. Ka kakaretso e mamelleha hantle, empa tlhokomelo ea hlokahala
Ho bonahala Nattokinase e mamelleha hantle lithutong tse 'maloa tsa batho, empa e hloka tšebeliso e nang le boikarabelo ka lebaka la tšusumetso ea eona e ka bang teng litseleng tsa ho hoama ha mali.
Phuputso ea kliniki ea bophelo ba sebele e hlahlobile nattokinase ka 100 mg ka letsatsi ho bakuli ba amohetsoeng opereisheneng ea methapo ea mali. Bafuputsi ba tlalehile lintho tse hlokometsoeng tse tšehetsang polokeho ea tšebeliso ea nattokinase boemong bona, leha tlhokomelo ea bongaka ea motho ka mong e ntse e le ea bohlokoa, haholo-holo bakeng sa batho ba nkang meriana ea anticoagulant kapa antiplatelet (Galelli le ba bang, 2021).
Kaha nattokinase e ka ama fibrinolysis le matšoao a amanang le ho bola ha mali, e kanna ea se ke ea lokela motho e mong le e mong. Batho ba nkang meriana e fokotsang mali, aspirin, meriana e thibelang ho ruruha ha mali, kapa meriana e thibelang ho ruruha ha mali, hammoho le ba nang le mathata a ho tsoa mali, opereishene e tlang, boimana, kapa maemo a tebileng a bophelo, ba lokela ho batla keletso ea bongaka pele ba sebelisa nattokinase.
Nattokinase ke enzyme e ikhethang e nkiloeng ho soya e belisitsoeng 'me e tsebahala haholo ka karolo ea eona e ka bang teng ho tšehetseng bophelo bo botle ba pelo le methapo ea mali. Libaka tsa eona tse matla ka ho fetisisa tsa lipatlisiso li kenyelletsa:
- Tšehetso e phetseng hantle ea phallo ea mali
- Mosebetsi oa Fibrinolytic
- Ho leka-lekana ha khatello ea mali
- Tšehetso ea letšoao la methapo ea mali
- Metabolism ea lipid le bophelo bo botle ba methapo ea mali ho batho ba khethiloeng
Diphuputso tse fumanehang di a tshepisa, empa ha di tsitsane ka botlalo. Diphuputso tse ding di bontsha dintlafatso tse nang le moelelo kgatellong ya madi, tshebetso ya fibrinolytic, le matshwao a pelo le methapo ya madi, ha tse ding di bontsha phello e fokolang kapa e se nang yona, haholoholo ho batho ba phetseng hantle ba nang le kotsi e tlase. Sena se fana ka maikutlo a hore nattokinase e ka sebetsa ka tsela e fapaneng ho latela boemo ba bophelo ba motho ka mong, tekanyo, nako le boleng ba sehlahiswa.
Nattokinase e lokela ho nkoa e le motsoako o thusang ho feta kalafo kapa pheko. Ha e sebelisoa ka boikarabelo, e ka ba tlatsetso ea bohlokoa mefuteng ea bophelo bo botle ba pelo le methapo ea mali, haholo-holo e shebaneng le ho potoloha ha mali, botsofali bo botle le botsitso ba metabolism.
ikgololo: Polelo ena ha e so hlahlojoe ke EFSA, KFDA kapa FDA. Sehlahisoa sena ha sea rereloa ho hlahloba, ho phekola, ho folisa, kapa ho thibela lefu lefe kapa lefe. Leha tlhahisoleseling e fanoeng e thehiloe litšupisong tse tšepahalang, ha re etse likopo kapa litiisetso tse tobileng. Ho bohlokoa ho buisana le moeletsi oa hau oa tlhokomelo ea bophelo bakeng sa likeletso le tataiso e ikhethileng e amanang le bophelo ba hau.
References
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