Nattokinase ienzyme inotorwa kubva ku natto, chikafu chechinyakare chekuJapan chinogadzirwa nekuvirisa soya neBacillus subtilis natto. Yawana kufarira kwesainzi nekuda kwebasa rayo rinogona kuita mukutsigira hutano hwemwoyo, kuyerera kweropa kwakanaka, uye kutenderera kweropa kwakajairika. Nattokinase inozivikanwa zvakanyanya nebasa rayo re fibrinolytic, zvichireva kuti inogona kubatsira kutsigira maitiro emuviri ekupwanya fibrin, puroteni inobatsira pakuumbwa kweropa.
Kusiyana nezvimwe zvinhu zvakawanda zvinosanganisa zvirimwa, nattokinase chinhu chinoshanda nema enzyme. Yakaongororwa kuti inogona kukanganisa sei BP, viscosity yeropa, zviratidzo zvine chekuita neropa, metabolism yemafuta, uye hutano hwetsinga dzeropa. Zvisinei, humbowo huripo huchiri kukura, uye mhedzisiro inosiyana zvichienderana nechiyero, dhizaini yekudzidza, huwandu hwevanhu, uye nguva. Pazasi pane zvimwe zvingangobatsira pahutano hwe nattokinase zvichibva pakutsvagurudza kwesainzi.
1. Inotsigira Kuyerera Kweropa Kwakanaka uye Basa reFibrinolytic
Nattokinase inogona kutsigira kutenderera kweropa mumuviri nekubatsira muviri kuchengetedza fibrin yakaringana uye nzira dzechisikigo dzekupwanya maronda.
Muongororo ine musoro unoti Nattokinase: Mushonga weKurwisa Kuputika Kweropa Mumuromo weKudzivirira Chirwere cheMwoyo, vaongorori vakatsanangura nattokinase seenzyme yefibrinolytic ine simba rekutsigira mwoyo. Ongororo iyi inotsanangura kuti nattokinase inogona kubatsira kuputsa fibrin zvakananga uye inogonawo kutsigira hurongwa hwemuviri hwefibrinolytic nekuchinja plasmin nedzimwe nzira dzine chekuita nekuvhara ropa. Maitiro aya anoratidza kuti nattokinase inogona kuita basa rekutsigira kuyerera kweropa kwakanaka uye kushanda kwetsinga dzeropa (Weng et al., 2017).
Imwe ongororo, Nattokinase: Imwe Nzira Inovimbisa Mukudzivirira neKurapa Zvirwere zveMwoyo, yakakurukura nattokinase seimwe yezvikamu zvinonyanya kushanda zvenatto. Vanyori vakaratidza migumisiro yayo pa fibrinolysis, BP, metabolism yemafuta, uye zviratidzo zvine chekuita ne atherosclerosis. Zvisinei, vakataurawo kuti zvidzidzo zvakawanda zvevanhu zvinodiwa kuti zvisimbise kukosha kwayo mukurapa, chiyero chakakodzera, uye kuchengetedzeka kwenguva refu mumapoka akasiyana (Chen et al., 2018).
2. Inogona Kubatsira Kuchengetedza Kushushikana Kweropa Kwakanaka
Nattokinase yakaongororwa nekuda kwebasa rayo rinogona kuitwa mukutsigira BP yakajairika, kunyanya kuvanhu vane BP yakakwira.
Muongororo yakaitwa neboka revanhu vaviri, isina kubatwa nemaziso, uye yakadzorwa neboka revanhu, vaongorori vakaongorora vanhu vakuru 86 vane makore ari pakati pe20 kusvika 80 vane BP yesystolic isina kurapwa iri pakati pe130 ne159 mmHg. Vatori vechikamu vakapihwa nattokinase pa2,000 FU pazuva kana placebo kwemavhiki masere. Vatori vechikamu makumi manomwe nevatatu vakapedza kudzidza. Zvichienzaniswa neplacebo, nattokinase yakabatana nekudzikira kweBP yesystolic nediastolic, nekuchinja kweanenge -5.55 mmHg uye -2.84 mmHg, zvichiteerana. Chidzidzo ichi chakaonawo kudzikira kwekushanda kweplasma renin, zvichiratidza kuti pane nzira inogona kunge iine chekuita nekudzora BP (Kim et al., 2008).
Mune imwe ongororo yekuNorth America yakaitwa nemaitiro asina kujeka, isina kupofumadzwa kaviri, uye yakadzorwa ne placebo, vanhu 79 vaiva neBP yakakwira vakadya 100 mg ye nattokinase zuva nezuva kana placebo kwemavhiki masere. Chidzidzo ichi chakaongorora zviratidzo zveBP nenjodzi dzemwoyo, kusanganisira von Willebrand factor. Zvakawanikwa zvakaratidza kuti kudyiwa kwe nattokinase kwakabatana nekudzikira kweBP uye kudzikira kwe von Willebrand factor, chiratidzo chakabatana nehutano hwetsinga dzeropa uye kushanda kwekuvhara ropa (Jensen et al., 2016).
Zvidzidzo izvi zvinoratidza kuti nattokinase inogona kutsigira kuenzana kweropa mumapoka akati wandei. Zvisinei, haifanirwe kutorwa senzira yekutsiva mishonga yakanyorerwa yekuderedza BP kana kurapwa.
3. Inogona Kutsigira Kuyera Njodzi dzeMwoyo
Nattokinase inogona kubatsira kutsigira hutano hwemwoyo nekubatsira zviratidzo zvakasiyana zvine chekuita nekugwamba kweropa, mashandiro etsinga dzeropa, uye kutenderera kweropa.
Chidzidzo chakaitwa naJensen et al. (2016) chakakosha zvikuru nekuti hachina kungoongorora BP chete asiwo chakayera von Willebrand factor uye platelet factor-4. Von Willebrand factor inobatanidzwa mukunamatira kweplatelet uye kuumbwa kweclot. Kuderedzwa kwechiratidzo ichi kunogona kuratidza mhedzisiro inotsigira kuenzana kwetsinga dzeropa neropa. Zvisinei, izvi hazvirevi kuti nattokinase inodzivirira zviitiko zvemwoyo, sezvo miedzo mikuru uye yakareba yekiriniki ichidikanwa kusimbisa mhedzisiro yakadaro (Jensen et al., 2016).
Ongororo yakarongeka ya2023 uye meta-analysis ine musoro unoti Nattokinase Supplementation and Cardiovascular Risk Factors yakaongorora miedzo yakarongwa isina kurongeka pa nattokinase ne cardiovascular markers. Ongororo iyi yakawana kuti nattokinase supplementation yakabatana nekudzikira kudiki kwe systolic ne diastolic blood pressure. Zvisinei, vanyori vakataurawo kuti humbowo hwezvimwe zviratidzo, kusanganisira lipids ne coagulation outcomes, hwakanga husina kurongeka muzvidzidzo (Li et al., 2023).
Kazhinji, nattokinase inogona kutsigira zviratidzo zvemwoyo zvakasarudzwa, asi mhedzisiro yayo inoita seinoenderana nehuwandu hwevanhu vakaongororwa, huwandu hwemushonga, kurongeka kwemushonga, uye nguva yekushandiswa.
4. Inogona Kubatsira Kutsigira Kugayiwa Kwemafuta Mumuviri Uye Hutano HweArterial
Dzimwe ongororo dzinoratidza kuti nattokinase inogona kutsigira lipid metabolism uye hutano hwetsinga dzeropa, asi humbowo hahuna kuenderana zvizere.
Muchidzidzo chekiriniki che carotid artery atherosclerosis uye hyperlipidemia, kuwedzera nattokinase kwakaongororwa kuti kwakakosha sei pakukora kwe carotid intima-media, saizi yeplaque, uye lipid profile. Zvakawanikwa zvakaratidza kuti nattokinase inogona kuderedza kuyerwa kweplaque uye kugadzirisa mamwe lipid markers muvanhu vane atherosclerosis uye lipids yakakwira (Ren et al., 2017).
Chidzidzo chakazotevera chakaongorora huwandu hwe nattokinase hwakakwira pazuva, 10,800 FU pazuva, maererano nekufambira mberi kwe atherosclerosis uye hyperlipidemia. Vaongorori vakashuma kuti huwandu uhwu hwakabatana nekuvandudzika kwehuwandu hwemafuta mumuviri uye zviyero zvine chekuita ne atherosclerosis. Zvisinei, zvakawanikwa pahuwandu hwepamusoro hazvifanirwe kuverengerwa kune zvese zvigadzirwa zve nattokinase kana madhigirii ekuwedzera akajairwa pasina kuongororwa kwakanyatsojeka (Chen et al., 2022).
Panguva imwe chete, hazvisi zvese zvidzidzo zvakaratidza mhedzisiro yakanaka. Chidzidzo cheNattokinase Atherothrombotic Prevention Study, ongororo yakarongwa nevanhu vane hutano vane njodzi shoma yemwoyo, yakawana kuti kuwedzera nattokinase hakuna kukanganisa zvakanyanya kufambira mberi kwechirwere cheatherosclerosis, BP, kana zviratidzo zverabhoritari mushure menguva yepakati yekurapwa kwemakore matatu (Hodis nevamwe, 2021).
Musiyano uyu unoratidza kuti nattokinase inogona kunge yakakosha kune vanhu vakasiyana, kunyanya avo vane njodzi yemwoyo, pane vanhu vane hutano hwakanaka vane njodzi shoma.
5. Inogona Kupa Rutsigiro Sechikamu Chenzira Yehutano Hwemwoyo
Nattokinase dzimwe nguva inodzidzwa pamwe chete nezvimwe zvinhu zvinoshanda, kunyanya muongororo yehutano hwemwoyo.
Muongororo yakaitwa muna 2024 isina kurongeka, isina kupofumadzwa kaviri, uye yakadzorwa ne placebo, vaongorori vakadzidza nattokinase yakabatana nemupunga mutsvuku wembiriso muvarwere vane chirwere chemwoyo chakasimba. Chidzidzo ichi chakaongorora mhedzisiro yekuderedza mafuta mumuviri, kuderedza BP, uye kurwisa thrombosis. Zvakabuda zvakaratidza kuti musanganiswa uyu unogona kuvandudza mamwe ma parameter e cardiometabolic, kunyangwe zvakakosha kuziva kuti iyi yaive ongororo yemusanganiswa. Saka, mabhenefiti acho haagone kuverengerwa ku nattokinase chete (Liu et al., 2024).
Rudzi urwu rwekutsvaga rwakakosha nekuti hutano hwemwoyo hunokonzerwa nezvinhu zvakawanda, zvinosanganisira kudya, kurovedza muviri, huwandu hwemafuta mumuviri, BP, kuzvimba, kushushikana kwe oxidative, uye majini. Nattokinase inogona kukodzera muhurongwa hwakakura hwehutano, asi inofanira kuiswa sechinhu chinotsigira pane mhinduro yega.
6. Kazhinji Inoshivirirwa Zvakanaka, Asi Kutarisirwa Kunodiwa
Nattokinase inoratidzika kunge inowanzo bvumidzwa zvakanaka muzvidzidzo zvakasiyana-siyana zvevanhu, asi inoda kushandiswa zvine hungwaru nekuda kwemhedzisiro yayo panzira dzekugwamba kweropa.
Ongororo yekiriniki chaiyo yakaongorora nattokinase pa100 mg pazuva muvarwere vakabvumirwa kuvhiyiwa kwetsinga dzeropa. Vaongorori vakataura zvakaonekwa zvichitsigira kuchengetedzeka kwekushandiswa kwenattokinase munzvimbo iyi, kunyange hazvo kutarisirwa kwemunhu mumwe nemumwe kuchikosha, kunyanya kune vanhu vanotora mishonga inorwisa ropa kana mishonga inorwisa maplatelet (Galelli nevamwe, 2021).
Sezvo nattokinase ichigona kukanganisa fibrinolysis uye zviratidzo zvine chekuita neropa, inogona kusakodzera munhu wese. Vanhu vanotora mishonga inobvisa ropa, aspirin, mishonga inorwisa ropa, kana mishonga inorwisa maplatelet, pamwe chete nevaya vane matambudziko ekubuda ropa, kuvhiyiwa kuri kuuya, pamuviri, kana zvirwere zvakakomba, vanofanira kutsvaga mazano echiremba vasati vashandisa nattokinase.
Nattokinase ienzyme yakasiyana inotorwa kubva musoya dzakaviriswa uye inozivikanwa zvikuru nebasa rayo rinogona kubatsira mukuchengetedza hutano hwemwoyo neropa. Nzvimbo dzayo dzakasimba dzekutsvaga dzinosanganisira:
- Rutsigiro rwekuyerera kweropa kwakanaka
- Basa reFibrinolytic
- Kuenzana kweropa
- Rutsigiro rwezviratidzo zvetsinga dzeropa
- Kugayiwa kwemafuta mumuviri uye hutano hwetsinga muvanhu vakasarudzwa
Ongororo iripo inoratidza kufambira mberi kwakanaka muropa, kushanda kwe fibrinolytic, uye zviratidzo zvemwoyo, nepo zvimwe zvichiratidza mhedzisiro shoma kana kuti isina, kunyanya kuvanhu vane hutano hwakanaka vane njodzi shoma. Izvi zvinoratidza kuti nattokinase inogona kushanda zvakasiyana zvichienderana nemamiriro ehutano hwemunhu, uwandu, nguva, uye mhando yechigadzirwa.
Nattokinase inofanira kuonekwa sechinhu chinotsigira pane kurapwa kana kurapa. Kana ikashandiswa zvine mwero, inogona kuva chinhu chinokosha pakurapa kwemwoyo, kunyanya iyo inotarisa pakuyerera kweropa, kukwegura kwakanaka, uye kuenzana kwemetabolism.
Disclaimer: Chirevo ichi hachina kuongororwa neEFSA, KFDA kana FDA. Chigadzirwa ichi hachina chinangwa chekuongorora, kurapa, kurapa, kana kudzivirira chero chirwere. Kunyange zvazvo ruzivo rwakapihwa rwakavakirwa pamagwaro akavimbika, hatiite chero zvichemo kana vimbiso chaiyo. Zvakakosha kubvunza mupi wezano wehutano hwako kuti uwane mazano akakodzera uye gwara rine chekuita nehutano hwako.
References
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