Ubwino wa Nattokinase pa Thanzi la Mtima ndi Kuyenda kwa Mtsempha

Nattokinase ndi enzyme yachilengedwe yochokera ku natto, chakudya chachikhalidwe cha ku Japan chopangidwa ndi soya wopangidwa ndi Bacillus subtilis natto. Yapeza chidwi cha sayansi chifukwa cha ntchito yake yothandizira thanzi la mtima, kuyenda bwino kwa magazi, komanso kuyenda bwino kwa magazi. Nattokinase imadziwika kwambiri ndi ntchito yake ya fibrinolytic, zomwe zikutanthauza kuti ingathandize kuthandizira njira yachilengedwe yophwanya fibrin, puloteni yomwe imakhudza kupanga magazi. 

Mosiyana ndi zosakaniza zambiri za zomera, nattokinase ndi chinthu chogwira ntchito chochokera ku ma enzyme. Chafufuzidwa kuti chione momwe chingakhudzire kuthamanga kwa magazi, kukhuthala kwa magazi, zizindikiro zokhudzana ndi magazi kuundana, kagayidwe ka mafuta m'thupi, ndi thanzi la mitsempha yamagazi. Komabe, umboni womwe ulipo ukupitirirabe, ndipo zotsatira zake zimasiyana malinga ndi mlingo, kapangidwe ka kafukufuku, kuchuluka kwa anthu, ndi nthawi. Pansipa pali maubwino angapo a nattokinase pa thanzi kutengera kafukufuku wasayansi. 

1. Imathandizira Kuyenda Kwa Magazi Kwathanzi ndi Ntchito Yolimbitsa Thupi

Nattokinase ingathandize kuti magazi aziyenda bwino m'thupi mwa kuthandiza thupi kukhala ndi ulusi wabwinobwino komanso kuti magazi azituluka m'thupi. 

Mu ndemanga yotchedwa Nattokinase: Wothandizira Pakamwa Woletsa Kutsekeka kwa Matenda a Mtima, ofufuza adafotokoza nattokinase ngati enzyme ya fibrinolytic yokhala ndi mphamvu zothandizira mtima. Ndemangayi ikufotokoza kuti nattokinase ingathandize kuswa fibrin mwachindunji ndipo ingathandizenso dongosolo la thupi la fibrinolytic pokhudza plasmin ndi njira zina zokhudzana ndi magazi kuundana. Njirazi zikusonyeza kuti nattokinase ingathandize kuthandizira kuyenda bwino kwa magazi ndi ntchito ya mitsempha yamagazi ( Weng et al., 2017 ).

Ndemanga ina, Nattokinase: Njira Yolonjeza mu Kupewa ndi Kuchiza Matenda a Mtima, inafotokoza za nattokinase ngati imodzi mwa zigawo zogwira ntchito kwambiri za natto. Olembawo adawonetsa zotsatira zake pa fibrinolysis, kuthamanga kwa magazi, kagayidwe ka mafuta m'thupi, ndi zizindikiro zokhudzana ndi atherosclerosis. Komabe, adawonanso kuti maphunziro ambiri a anthu akufunika kuti atsimikizire kufunika kwake kuchipatala, mlingo woyenera, komanso chitetezo cha nthawi yayitali m'magulu osiyanasiyana ( Chen et al., 2018 ).

2. Zingathandize Kusunga Kuthamanga kwa Magazi Kwabwino

Nattokinase yaphunziridwa chifukwa cha ntchito yake yothandizira kuthamanga kwa magazi kwabwinobwino, makamaka kwa anthu omwe ali ndi kuthamanga kwa magazi kokwera. 

Mu kafukufuku wosankhidwa mwachisawawa, wosawoneka bwino, komanso wolamulidwa ndi placebo, ofufuza adafufuza akuluakulu 86 azaka zapakati pa 20 ndi 80 omwe anali ndi kuthamanga kwa magazi kwa systolic komwe sikunachiritsidwe pakati pa 130 ndi 159 mmHg. Ophunzira adalandira nattokinase pa 2,000 FU patsiku kapena placebo kwa masabata 8. Ophunzira 73 adamaliza kafukufukuyu. Poyerekeza ndi placebo, nattokinase idalumikizidwa ndi kuchepa kwa kuthamanga kwa magazi kwa systolic ndi diastolic, ndi kusintha konse kwa pafupifupi -5.55 mmHg ndi -2.84 mmHg, motsatana. Kafukufukuyu adawonanso kuchepa kwa ntchito ya renin m'magazi, zomwe zikusonyeza njira yomwe ingakhale yogwirizana ndi kulamulira kuthamanga kwa magazi ( Kim et al., 2008 ).

Mu kafukufuku wina wa ku North America wochitidwa mwachisawawa, wosawoneka bwino, komanso wolamulidwa ndi placebo, anthu 79 omwe anali ndi kuthamanga kwa magazi kwambiri adadya 100 mg ya nattokinase tsiku lililonse kapena placebo kwa milungu 8. Kafukufukuyu adafufuza zizindikiro zokhudzana ndi kuthamanga kwa magazi ndi zoopsa za mtima, kuphatikizapo von Willebrand factor. Zomwe zapezekazi zikusonyeza kuti kumwa nattokinase kunagwirizana ndi kuchepa kwa kuthamanga kwa magazi komanso kuchepa kwa von Willebrand factor, chizindikiro chogwirizana ndi thanzi la mitsempha yamagazi komanso ntchito yotseka magazi ( Jensen et al., 2016 ).

 Kafukufukuyu akusonyeza kuti nattokinase ingathandize kuti magazi aziyenda bwino m'magulu ena. Komabe, siyenera kuonedwa ngati njira yolowa m'malo mwa mankhwala ochepetsa kuthamanga kwa magazi kapena chithandizo chamankhwala choperekedwa ndi dokotala. 

3. Ingathandize Kuwerengera Chiwopsezo cha Mtima ndi Mitsempha

Nattokinase ingathandize kuthandizira thanzi la mtima mwa kusintha zizindikiro zina zokhudzana ndi magazi kuundana, ntchito ya mitsempha yamagazi, ndi kuyenda kwa magazi m'thupi. 

Kafukufuku wochitidwa ndi Jensen et al. (2016) ndi wofunika kwambiri chifukwa sunangoyang'ana kuthamanga kwa magazi komanso unayesa von Willebrand factor ndi platelet factor-4. Von Willebrand factor imakhudzidwa ndi kumamatira kwa platelet ndi kupanga magazi. Kuchepetsa chizindikirochi kungasonyeze kuti kumathandizira pakuyenda bwino kwa mitsempha yamagazi ndi kayendedwe ka magazi. Komabe, izi sizikutanthauza kuti nattokinase imaletsa zochitika zamtima, chifukwa mayeso akuluakulu komanso aatali akufunika kuti atsimikizire zotsatira zotere ( Jensen et al., 2016 ).

Kuwunikanso mwadongosolo kwa 2023 ndi kusanthula kwa meta komwe kumadziwika kuti Nattokinase Supplementation and Cardiovascular Risk Factors kunayesa mayeso olamulidwa mwachisawawa pa zizindikiro za nattokinase ndi mtima. Kuwunikaku kunapeza kuti kuwonjezera nattokinase kunagwirizanitsidwa ndi kuchepa pang'ono kwa kuthamanga kwa magazi kwa systolic ndi diastolic. Komabe, olembawo adawonanso kuti umboni wa zizindikiro zina, kuphatikizapo zotsatira za lipid ndi coagulation, sunali wofanana kwambiri pa maphunziro onse ( Li et al., 2023 ).

Ponseponse, nattokinase ikhoza kuthandizira zizindikiro zina za mtima, koma zotsatira zake zimawoneka kuti zimadalira kuchuluka kwa anthu omwe akuphunzira, mlingo, muyezo wa mankhwala, ndi nthawi yogwiritsira ntchito. 

4. Zingathandize Kuthandiza Kugayidwa kwa Mafuta ndi Thanzi la Mitsempha

Kafukufuku wina akusonyeza kuti nattokinase ingathandize kagayidwe ka mafuta m'thupi komanso thanzi la mitsempha yamagazi, koma umboni wake sukufanana mokwanira. 

Mu kafukufuku wa zachipatala wokhudza atherosclerosis ya mitsempha ya carotid ndi hyperlipidemia, kuwonjezera kwa nattokinase kunafufuzidwa kuti kuone momwe kumakhudzira makulidwe a carotid intima-media, kukula kwa plaque, ndi mbiri ya lipid. Zomwe zapezekazi zikusonyeza kuti nattokinase ikhoza kuchepetsa miyeso yokhudzana ndi plaque ndikukweza zizindikiro zina za lipid mwa omwe ali ndi atherosclerosis ndi lipids zokwera ( Ren et al., 2017 ).

Kafukufuku wina wotsatira adafufuza mlingo wokwera wa nattokinase tsiku lililonse, 10,800 FU patsiku, poyerekeza ndi kupita patsogolo kwa atherosclerosis ndi hyperlipidemia. Ofufuzawo adanenanso kuti mlingo uwu unagwirizana ndi kusintha kwa mbiri ya lipid ndi miyeso yokhudzana ndi atherosclerosis. Komabe, zomwe zapezeka pa mlingo waukulu siziyenera kugawidwa pazinthu zonse za nattokinase kapena milingo yowonjezera yokhazikika popanda kuwunika mosamala ( Chen et al., 2022 ).

Nthawi yomweyo, si maphunziro onse omwe asonyeza zotsatira zabwino. Kafukufuku wa Nattokinase Atherothrombotic Prevention Study, woyesedwa mwachisawawa mwa anthu athanzi omwe ali ndi chiopsezo chochepa cha mtima ndi mitsempha yamagazi, adapeza kuti kuwonjezera nattokinase sikunakhudze kwambiri kupita patsogolo kwa atherosclerosis, kuthamanga kwa magazi, kapena zizindikiro za labotale pambuyo pa nthawi yapakati ya chithandizo cha zaka 3 ( Hodis et al., 2021 ).

Kusiyana kumeneku kukusonyeza kuti nattokinase ikhoza kukhala yofunikira kwambiri kwa anthu ena, makamaka omwe ali ndi matenda enaake a mtima, m'malo mwa anthu athanzi omwe ali pachiwopsezo chochepa. 

5. Angapereke Chithandizo Monga Gawo la Njira Yothandizira Moyo Wabwino wa Cardiometabolic

Nattokinase nthawi zina imaphunziridwa pamodzi ndi zinthu zina zothandiza, makamaka mu kafukufuku wa thanzi la mtima ndi kagayidwe kake ka thupi. 

Mu kafukufuku wa 2024 wosankhidwa mwachisawawa, wosawoneka bwino, komanso wolamulidwa ndi placebo, ofufuza adaphunzira nattokinase yophatikizidwa ndi mpunga wofiira wa yisiti mwa odwala omwe ali ndi matenda okhazikika a mitsempha ya mtima. Kafukufukuyu adafufuza zotsatira zochepetsa mafuta m'thupi, kuchepetsa kuthamanga kwa magazi, komanso zotsutsana ndi thrombosis. Zotsatira zake zidawonetsa kuti kuphatikizaku kungathandize kusintha magawo ena a cardiometabolic, ngakhale ndikofunikira kuzindikira kuti uwu unali kafukufuku wophatikizana. Chifukwa chake, zabwino zake sizingatchulidwe ndi nattokinase yokha ( Liu et al., 2024 ).

Kafukufuku wamtunduwu ndi wofunikira chifukwa thanzi la mtima limakhudzidwa ndi zinthu zambiri, kuphatikizapo zakudya, masewera olimbitsa thupi, kuchuluka kwa mafuta m'thupi, kuthamanga kwa magazi, kutupa, kupsinjika kwa okosijeni, ndi majini. Nattokinase ikhoza kukhala yoyenera mu njira yayikulu yopezera thanzi, koma iyenera kuyikidwa ngati chothandizira m'malo mwa yankho lokha. 

6. Kawirikawiri zimalekerera bwino, koma chisamaliro chikufunika

Kafukufuku wosiyanasiyana wa anthu akuwoneka kuti Nattokinase nthawi zambiri imavomerezedwa bwino, koma imafuna kugwiritsidwa ntchito moyenera chifukwa cha momwe ingakhudzire njira zotsekereza magazi. 

Kafukufuku wa zachipatala weniweni adawunika nattokinase pa 100 mg patsiku mwa odwala omwe adavomerezedwa ku opaleshoni ya mitsempha yamagazi. Ofufuzawo adanenanso zomwe zapezeka kuti zikugwirizana ndi chitetezo cha kugwiritsa ntchito nattokinase pamalo awa, ngakhale kuyang'aniridwa ndi dokotala payekha ndikofunikira, makamaka kwa anthu omwe akumwa mankhwala oletsa magazi kuundana kapena oletsa magazi kuundana ( Galelli et al., 2021 ).

Popeza nattokinase ingakhudze fibrinolysis ndi zizindikiro zokhudzana ndi magazi kuundana, sizingakhale zoyenera aliyense. Anthu omwe akumwa mankhwala ochepetsa magazi, aspirin, mankhwala oletsa magazi kuundana, kapena mankhwala oletsa magazi kutuluka magazi, komanso omwe ali ndi vuto la kutuluka magazi, opaleshoni yomwe ikubwera, mimba, kapena matenda aakulu, ayenera kufunafuna upangiri wa dokotala asanayambe kugwiritsa ntchito nattokinase. 

Nattokinase ndi enzyme yapadera yochokera ku soya yophikidwa ndipo imadziwika bwino chifukwa cha ntchito yake yothandizira thanzi la mtima ndi mitsempha yamagazi. Madera ake amphamvu ofufuza ndi awa: 

• Thandizo la kuyenda bwino kwa magazi 
• Ntchito ya Fibrinolytic 
• Kuthamanga kwa magazi 
• Chithandizo cha chizindikiro cha mitsempha yamagazi 
• Kagayidwe ka lipid ndi thanzi la mitsempha yamagazi mwa anthu osankhidwa 

Kafukufuku amene alipo ndi wodalirika, koma sakugwirizana kwathunthu. Kafukufuku wina akuwonetsa kusintha kwakukulu kwa kuthamanga kwa magazi, ntchito ya fibrinolytic, ndi zizindikiro za mtima, pomwe ena akuwonetsa kuchepa kapena kusagwira ntchito, makamaka kwa anthu athanzi omwe ali pachiwopsezo chochepa. Izi zikusonyeza kuti nattokinase ingagwire ntchito mosiyana kutengera momwe munthu alili pa thanzi lake, mlingo wake, nthawi yake, ndi mtundu wa mankhwala. 

Nattokinase iyenera kuonedwa ngati chinthu chothandizira osati mankhwala kapena machiritso. Ikagwiritsidwa ntchito moyenera, ikhoza kukhala yowonjezerapo pazakudya za mtima, makamaka zomwe zimayang'ana kwambiri pakuyenda bwino kwa magazi, ukalamba wathanzi, komanso kagayidwe kachakudya m'thupi. 

Chodzikanira: Chiganizochi sichinawunikidwe ndi EFSA, KFDA kapena FDA. Chogulitsachi sichinapangidwe kuti chizindikire, kuchiza, kuchiritsa, kapena kupewa matenda aliwonse. Ngakhale kuti chidziwitso chomwe chaperekedwa chimachokera ku maumboni odalirika, sitipereka madandaulo kapena chitsimikizo chilichonse. Ndikofunikira kufunsa mlangizi wanu wazaumoyo kuti akupatseni upangiri ndi malangizo okhudzana ndi thanzi lanu.

Zothandizira 

• Chen, H., McGowan, EM, Ren, N., Lal, S., Nassif, N., Shad-Kaneez, F., Qu, X. ndi Lin, Y., 2018. Nattokinase: Njira ina yabwino yopewera ndi kuchiza matenda a mtima. Chidziwitso cha Biomarker, 13, masamba 1-8. 
• Chen, H., McGowan, EM, Ren, N., Lal, S., Nassif, N., Shad-Kaneez, F., Qu, X. ndi Lin, Y., 2022. Kuchita bwino kwa matenda a atherosclerosis ndi hyperlipidemia ndi nattokinase. Malire mu Cardiovascular Medicine. 
• Galelli, G., Cione, E., Caroleo, MC, Carullo, G., Genchi, G., Rende, P. ndi Citraro, R., 2021. Deta yolembedwa m'moyo weniweni imathandizira chitetezo cha nattokinase mwa odwala omwe ali ndi matenda amitsempha yamagazi. Mavitamini, 13 (6), tsamba 2031. 
• Hodis, HN, Mack, WJ, Dustin, L., Mahrer, PR ndi Azen, SP, 2021. Kafukufuku wopewera matenda a atherothrombotic wa Nattokinase: Kuyesa kolamulidwa mwachisawawa. Kuchiza kwa Hemorheology ndi Kuzungulira kwa Magazi Ochepa, 78(4), tsamba 339–353. 
• Jensen, GS, Lenninger, M., Ero, MP ndi Benson, KF, 2016. Kumwa nattokinase kumagwirizanitsidwa ndi kuchepa kwa kuthamanga kwa magazi ndi von Willebrand factor, chizindikiro cha chiopsezo cha mtima: Zotsatira kuchokera ku mayeso azachipatala aku North America omwe adachitika mwachisawawa, osawona kawiri, olamulidwa ndi placebo, komanso okhala ndi malo ambiri. Kulamulira Kuthamanga kwa Magazi Kogwirizana, 9, masamba 95-104. 
• Kim, JY, Gum, SN, Paik, JK, Lim, HH, Kim, KC, Ogasawara, K., Inoue, K., Park, S., Jang, Y. ndi Lee, JH, 2008. Zotsatira za nattokinase pa kuthamanga kwa magazi: Kuyesa kosasinthika komanso kolamulidwa. Kafukufuku wa Hypertension, 31(8), tsamba 1583–1588. 
• Li, X., Zheng, X., Liu, Y. ndi Zhang, Y., 2023. Kuonjezera Nattokinase ndi zinthu zoopsa za mtima: Kuwunikanso mwadongosolo ndi kusanthula kwa meta. Ndemanga mu Cardiovascular Medicine, 24 (8), tsamba 234. 
• Liu, M., Zhang, H., Wang, Y., Li, X. ndi Chen, J., 2024. Zotsatira za nattokinase zochepetsa mafuta m'thupi, kuchepetsa kuthamanga kwa magazi, komanso kuchepetsa magazi m'mitsempha pamodzi ndi mpunga wofiira wa yisiti mwa odwala omwe ali ndi matenda okhazikika a mitsempha ya mtima: Kuyesa kosankhidwa mwachisawawa, kopanda khungu kawiri, kolamulidwa ndi placebo. Malire mu Zakudya Zakudya. 
• Ren, NN, Chen, HJ, Li, Y., McGowan, E. ndi Lin, YG, 2017. Kafukufuku wa zachipatala pa zotsatira za nattokinase pa atherosclerosis ya mitsempha ya carotid ndi hyperlipidaemia. Zhonghua Yi Xue Za Zhi, 97(26), tsamba 2038–2042. 
• Weng, Y., Yao, J., Sparks, S. ndi Wang, KY, 2017. Nattokinase: Mankhwala oletsa magazi kutuluka m'magazi omwe amaletsa matenda a mtima. International Journal of Molecular Sciences, 18 (3), tsamba 523. 
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