Ko te Nattokinase he whākōkī tūturu i tangohia mai i te natto, he kai tuku iho a Hapanihi i hangaia mā te whakapūkara i ngā pīni soya ki te Bacillus subtilis natto. Kua piki ake te hiahia o te pūtaiao nā tōna tūranga pea ki te tautoko i te oranga o te ngākau, te rere o te toto, me te tohanga toto noa. E mōhiotia whānuitia ana te Nattokinase mō tana mahi fibrinolytic, arā, ka āwhina pea i te tukanga tūturu o te tinana ki te wawahi i te fibrin, he pūmua e uru ana ki te hanganga toto totoka.
He rerekē te nattokinase i te nuinga o ngā kai tipu, he kai mahi kei roto i te whākōkī. Kua rangahaua mō ōna pānga pea ki te toto toto, te matotoru o te toto, ngā tohu e pā ana ki te toto totoka, te pākia o te ngako, me te hauora o ngā uaua toto. Heoi, kei te whanake tonu ngā taunakitanga e wātea ana, ā, he rerekē ngā hua i runga i te horopeta, te hoahoa rangahau, te taupori, me te roa. Kei raro nei ētahi painga hauora pea o te nattokinase i runga i te rangahau pūtaiao.
1. Tautoko i te Rere Toto Hauora me te Mahi Fibrinolytic
Ka tautoko pea te Nattokinase i te tohanga toto hauora mā te āwhina i te tinana kia mau tonu te taurite o te fibrin me ngā tikanga pakaru toto totoka taiao.
I roto i tētahi arotake i tapaina ko Nattokinase: He Ākena Ārai-Trombotic ā-Waha mō te Ārai i te Mate Cardiovascular, i whakaahuahia e ngā kairangahau te nattokinase hei whākōkī fibrinolytic me ngā āhuatanga tautoko-cardiovascular pea. E whakamārama ana te arotake ka āwhina pea te nattokinase ki te wawahi tika i te fibrin, ā, ka tautoko pea i te pūnaha fibrinolytic o te tinana mā te awe i te plasmin me ētahi atu ara e pā ana ki te toto toto. E kī ana ēnei tikanga ka whai wāhi pea te nattokinase ki te tautoko i te rere toto hauora me te mahi uaua (Weng et al., 2017).
I roto i tētahi atu arotake, ko Nattokinase: He Huarahi Whakatairanga mō te Ārai me te Maimoatanga o ngā Mate Pūnaha Cardiovascular, i kōrerohia te nattokinase hei tētahi o ngā wāhanga tino kaha o te natto. I whakanuia e ngā kaituhi ōna pānga pea ki te fibrinolysis, te toto toto tiketike, te pākia o te ngako, me ngā tohu e pā ana ki te atherosclerosis. Heoi, i kī anō rātou me nui ake ngā rangahau tangata hei whakaū i tōna hiranga haumanu, te horopeta pai, me te haumaru mō te wā roa i roto i ngā taupori rerekē (Chen et al., 2018).
2. Tērā pea ka āwhina i te pupuri i te toto toto hauora
Kua rangahaua te Nattokinase mō tōna tūranga pea ki te tautoko i te toto totoka kia noa, inā koa mō te hunga he teitei te toto totoka.
I roto i tētahi whakamātautau matapōkere, matapo-rua, whakahaere-placebo, i rangahauhia e ngā kairangahau he 86 ngā pakeke i waenga i te 20 ki te 80 tau te pakeke me te toto toto systolic kāore i rongoatia i waenga i te 130 me te 159 mmHg. I whiwhi ngā kaiuru i te nattokinase i te 2,000 FU ia rā, i te placebo rānei mō ngā wiki e 8. E whitu tekau mā toru ngā kaiuru i whakaoti i te rangahau. Ki te whakatauritea ki te placebo, i honoa te nattokinase ki te whakahekenga o te toto toto systolic me te diastolic, me ngā huringa kupenga tata ki te -5.55 mmHg me te -2.84 mmHg. I kitea anō hoki e te rangahau he whakahekenga o te mahi renin plasma, e kī ana he tikanga pea e pā ana ki te whakahaere toto toto (Kim et al., 2008).
I roto i tētahi atu rangahau matapōkere, matapo-rua, whakahaere-placebo o Amerika Te Raki, 79 ngā kaiuru me te toto toto tiketike i kai i te 100 mg nattokinase i ia rā, i te placebo rānei mō ngā wiki e 8. I tirotirohia e te rangahau te toto toto me ngā tohu e pā ana ki te mōrearea o te ngakau, tae atu ki te von Willebrand factor. I kī ngā kitenga he hononga te kai nattokinase ki te whakahekenga o te toto toto me te whakahekenga o te von Willebrand factor, he tohu e pā ana ki te hauora o ngā oko toto me te mahi toto totoka (Jensen et al., 2016).
E whakaatu ana ēnei rangahau ka taea e te nattokinase te tautoko i te taurite o te toto toto i roto i ētahi rōpū. Heoi, kaua e kiia he whakakapinga mō ngā rongoā whakaheke toto kua tohua, ngā maimoatanga hauora rānei.
3. Tērā pea ka tautoko i te taurite o te tohu mōrearea ngākau
Tērā pea ka āwhina a Nattokinase ki te tautoko i te oranga o te ngākau mā te awe i ngā tohu kua tīpakohia e pā ana ki te toto totoka, te mahi a ngā uaua toto, me te tohanga toto.
He mea tino nui te rangahau a Jensen et al. (2016) nā te mea kāore i te tirotiro noa i te toto toto engari i ine anō hoki i te von Willebrand factor me te platelet factor-4. Kei roto te Von Willebrand factor i te piri o te platelet me te hanganga toto totoka. Mā te whakahekenga o tēnei tohu ka tohu pea he pānga tautoko ki te taurite o ngā oko toto me te tohanga toto. Heoi, ehara tēnei i te kī ka ārai te nattokinase i ngā mate cardiovascular, nā te mea me nui ake, me roa ake ngā whakamātautau haumanu hei whakaū i aua putanga (Jensen et al., 2016).
I arotakehia e te arotake pūnaha me te tātaritanga whānui o te tau 2023 ko te taitara ko Nattokinase Supplementation and Cardiovascular Risk Factors ngā whakamātautau whakahaere matapōkere mō ngā tohu nattokinase me te cardiovascular. I kitea i roto i te arotakenga ko te tāpiringa nattokinase e pā ana ki te whakahekenga iti o te toto toto systolic me te diastolic. Heoi, i kī anō ngā kaituhi he iti ake te ōrite o ngā taunakitanga mō ētahi atu tohu, tae atu ki ngā hua lipid me te coagulation, puta noa i ngā rangahau (Li et al., 2023).
I te nuinga o te wā, ka tautoko pea te nattokinase i ētahi tohu mate ngakau, engari ko ōna pānga te āhua nei ka whakawhirinaki ki te taupori rangahau, te horopeta, te paerewa hua, me te roa o te whakamahinga.
4. Tērā pea ka āwhina i te tautoko i te metabolism lipid me te hauora o te uaua
E ai ki ētahi rangahau, tera pea ka tautoko te nattokinase i te pākia o te ngako me te hauora o ngā uaua, engari kāore i te tino ōrite ngā taunakitanga.
I roto i tētahi rangahau haumanu mō te atherosclerosis o te uaua carotid me te hyperlipidemia, i tirotirohia te tāpiringa nattokinase mō tōna pānga ki te matotoru o te intima-media carotid, te rahi o te papa, me te kōtaha lipid. I kī ngā kitenga ka taea e te nattokinase te whakaiti i ngā inenga e pā ana ki te papa me te whakapai ake i ētahi tohu lipid i roto i ngā kaiuru me te atherosclerosis me ngā lipid teitei (Ren me ētahi atu, 2017).
I muri mai, i tirotirohia e tētahi rangahau he horopeta nattokinase teitei ake i ia rā, 10,800 FU ia rā, e pā ana ki te whanaketanga o te atherosclerosis me te hyperlipidemia. I kōrero ngā kairangahau he hononga tēnei horopeta ki ngā whakapainga o te kōtaha lipid me ngā inenga e pā ana ki te atherosclerosis. Heoi, kaua ngā kitenga horopeta teitei e whānuitia ki ngā hua nattokinase katoa, ki ngā horopeta tāpiringa paerewa rānei me te kore e arotakehia marietia (Chen et al., 2022).
I taua wā anō, kāore i te katoa ngā rangahau i whakaatu i ngā hua pai. I kitea i roto i te Nattokinase Atherothrombotic Prevention Study, he whakamātautau matapōkere i roto i ngā tāngata hauora he iti te mōrearea o te ngakau, kāore te tāpiringa nattokinase i tino pā ki te whanaketanga o te atherosclerosis subclinical, te toto toto, ngā tohu taiwhanga rānei i muri i te wā maimoatanga toharite o te 3 tau (Hodis me ētahi atu, 2021).
E whakaatu ana tēnei rerekētanga he nui ake te hiranga o te nattokinase i roto i ētahi taupori kua tohua, inā koa ko te hunga he āhuatanga mōrearea mō te mate ngakau, kaua ki te hunga hauora iti te mōrearea.
5. Tērā pea ka tautoko hei wāhanga o te huarahi oranga Cardiometabolic
I ētahi wā ka rangahauhia te Nattokinase me ētahi atu kai whai hua, inā koa i roto i ngā rangahau hauora cardiometabolic.
I roto i tētahi whakamātautau matapōkere, matapo-rua, whakahaere-placebo i te tau 2024, i rangahauhia e ngā kairangahau te nattokinase i honoa ki te raihi rewena whero i roto i ngā tūroro he mate uaua ngakau pumau. I tūhuratia e te rangahau ngā pānga whakaheke-ngako, whakaheke toto, me te ārai-thrombotic. I kī ngā hua ka whakapai ake pea te whakakotahitanga i ētahi tawhā cardiometabolic, ahakoa he mea nui kia mōhio he rangahau whakakotahi tēnei. Nō reira, kāore e taea te kī ko te nattokinase anake ngā painga (Liu et al., 2024).
He mea nui tēnei momo rangahau nā te mea he maha ngā āhuatanga e pāngia ai te hauora o te ngākau me te ngākau, tae atu ki te kai, te korikori tinana, ngā taumata ngako, te toto toto tiketike, te mumura, te ahotea waikura, me ngā ira. Tērā pea ka uru te Nattokinase ki tētahi rautaki oranga whānui, engari me waiho hei wāhanga tautoko kaua hei otinga takitahi.
6. He pai te manawanui, engari me āta tupato
Te āhua nei he pai te manawanui o te Nattokinase i roto i ētahi rangahau i te tangata, engari me whakamahi tika nā te mea ka pā pea ki ngā ara toto totoka.
I arotakehia e tētahi rangahau haumanu tūturu te nattokinase i te 100 mg ia rā i roto i ngā tūroro i whakaurua ki te pokanga toto. I kōrero ngā kairangahau i ngā kitenga e tautoko ana i te haumaru o te whakamahinga o te nattokinase i roto i tēnei horopaki, ahakoa he mea nui tonu te tirotiro hauora takitahi, inā koa mō te hunga e tango ana i ngā rongoā anticoagulant, antiplatelet rānei (Gallelli me ētahi atu, 2021).
I te mea ka pā pea te nattokinase ki te fibrinolysis me ngā tohu e pā ana ki te toto totoka, kāore pea e pai mō te katoa. Ko te hunga e tango ana i ngā rongoā whakangawari toto, aspirin, anticoagulants, antiplatelet rānei, tae atu ki te hunga he mate toto, he pokanga kei te haere mai, he haputanga, he mate hauora kino rānei, me rapu tohutohu hauora i mua i te whakamahi i te nattokinase.
He whākōkī ahurei te Nattokinase i ahu mai i te pīni soya kua whakapūkaratia, ā, e mōhiotia whānuitia ana mō tōna tūranga pea ki te tautoko i te hauora o te pūnaha manawa me te toto. Ko ōna wāhanga rangahau tino kaha ko:
- Tautoko rere toto hauora
- Te mahi fibrinolytic
- Taurite toto toto
- Tautoko tohu toto
- Te pākia o te ngako me te hauora o ngā uaua toto i roto i ngā taupori kua tohua
He pai ngā rangahau e wātea ana, engari kāore i te tino ōrite. E whakaatu ana ētahi rangahau i ngā whakapainga nui o te toto toto, te mahi fibrinolytic, me ngā tohu cardiovascular, ko ētahi e whakaatu ana i te iti, i te kore rānei o te pānga, inā koa i roto i ngā tāngata hauora iti te mōrearea. E kī ana tēnei he rerekē te mahi a te nattokinase i runga i te āhua hauora o te tangata, te horopeta, te roa, me te kounga o te hua.
Me titiro ki te Nattokinase hei wāhanga tautoko mahi, kaua hei rongoā, hei rongoā rānei. Ina whakamahia tika, ka waiho pea hei tāpiritanga whai hua ki ngā hanganga hauora o te ngākau, inā koa ko ērā e aro ana ki te tohanga toto, te koroheketanga hauora, me te taurite o te pākia o te tinana.
Whakakape: Kāore anō kia arotakehia te kōrero e te EFSA, KFDA, FDA rānei. Kāore tēnei hua i te whakaarohia hei tātaritanga, hei rongoā, hei whakaora, hei ārai rānei i tētahi mate. Ahakoa i ahu mai ngā kōrero i whakaratohia i ngā tohutoro pono, kāore mātou e tuku kereme, i ngā taurangi motuhake rānei. He mea nui kia kōrero koe ki tō kaitohutohu hauora mō ngā tohutohu me ngā aratohu whaiaro e pā ana ki tō hauora.
Tohutoro
- Chen, H., McGowan, EM, Ren, N., Lal, S., Nassif, N., Shad-Kaneez, F., Qu, X. me Lin, Y., 2018. Nattokinase: He huarahi kē atu hei ārai me te rongoā i ngā mate pūnaha toto. Ngā Māramatanga mō ngā Tohu Koiora, 13, api.1–8.
- Chen, H., McGowan, EM, Ren, N., Lal, S., Nassif, N., Shad-Kaneez, F., Qu, X. me Lin, Y., 2022. Te whakahaere whai hua o te ahunga whakamua o te atherosclerosis me te hyperlipidemia me te nattokinase. Frontiers i roto i te rongoa Cardiovascular.
- Gallelli, G., Cione, E., Caroleo, MC, Carullo, G., Genchi, G., Rende, P. me Citraro, R., 2021. Ko ngā raraunga i tuhia i te ao tūturu e tautoko ana i te haumaru o te nattokinase i roto i ngā tūroro e pāngia ana e ngā mate toto. Ngā matūkai, 13 (6), wh.2031.
- Hodis, HN, Mack, WJ, Dustin, L., Mahrer, PR me Azen, SP, 2021. He rangahau ārai atherothrombotic a Nattokinase: He whakamātautau matapōkeretia whakahaeretia. Te Hemorheology Haumanu me te Microcirculation, 78 (4), pp.339–353.
- Jensen, GS, Lenninger, M., Ero, MP me Benson, KF, 2016. Ko te kai o te nattokinase e pā ana ki te whakahekenga o te toto toto me te take von Willebrand, he tohu mōrearea cardiovascular: Ngā hua mai i tētahi whakamātautau haumanu matapōkere, matapo-rua, whakahaere-placebo, maha-pokapū o Amerika Te Raki. Te Whakahaere Pēhanga Toto Whakauru, 9, api.95–104.
- Kim, JY, Gum, SN, Paik, JK, Lim, HH, Kim, KC, Ogasawara, K., Inoue, K., Park, S., Jang, Y. me Lee, JH, 2008. Ngā pānga o te nattokinase ki te toto toto: He whakamātautau matapōkere, whakahaeretia. Rangahau mō te toto toto tiketike, 31 (8), pp.1583–1588.
- Li, X., Zheng, X., Liu, Y. me Zhang, Y., 2023. Te tāpiringa Nattokinase me ngā āhuatanga mōrearea o te ngakau: He arotake pūnaha me te tātaritanga-maha. Nga arotake i roto i te rongoa Cardiovascular, 24 (8), wh.234.
- Liu, M., Zhang, H., Wang, Y., Li, X. me Chen, J., 2024. Ngā pānga whakaheke lipid, whakaheke toto, me te ārai toto o te nattokinase i honoa ki te raihi rewena whero i roto i ngā tūroro e mate ana i te mate uaua ngakau pumau: He whakamātautau matapōkere, matapō-rua, whakahaere-placebo. Frontiers in Nutrition.
- Ren, NN, Chen, HJ, Li, Y., McGowan, E. me Lin, YG, 2017. He rangahau haumanu mō te pānga o te nattokinase ki te atherosclerosis o te uaua carotid me te hyperlipidemia. Zhonghua Yi Xue Za Zhi, 97 (26), pp.2038–2042.
- Weng, Y., Yao, J., Sparks, S. me Wang, KY, 2017. Nattokinase: He rongoā ā-waha hei ārai i te toto totoka hei ārai i te mate manawa. Tuhinga o Nga Moutere Akoranga Motuhake, 18 (3), wh.523.
