Nattokinase bụ enzyme sitere n'okike nke a na-ewepụta site na natto, nri ọdịnala ndị Japan nke e ji Bacillus subtilis natto mee. Ọ nwetala mmasị sayensị n'ihi ọrụ ya nwere ike ịrụ n'ịkwado ahụike obi, ọbara dị mma, na mgbasa ọbara nkịtị. A maara Nattokinase karịsịa maka ọrụ fibrinolytic ya, nke pụtara na ọ nwere ike inye aka kwado usoro ebumpụta ụwa nke imebi fibrin, protein nke na-etinye aka na mmepụta mkpụkọ ọbara.
N'adịghị ka ọtụtụ ihe ndị e ji osisi mee, nattokinase bụ ihe na-arụ ọrụ nke dabere na enzyme. A mụọla ya maka mmetụta ya nwere ike inwe na ọbara mgbali elu, ọbara viscosity, ihe nrịbama metụtara klọọkụ, metabolism lipid, na ahụike akwara. Agbanyeghị, ihe akaebe dịnụ ka na-eto, nsonaazụ ya dịkwa iche dabere na dose, nhazi ọmụmụ ihe, ọnụọgụgụ mmadụ, na oge ọ na-ewe. N'okpuru ebe a bụ ọtụtụ uru ahụike nwere ike ịnweta nattokinase dabere na nchọpụta sayensị.
1. Na-akwado Ọrụ Ọbara Dị Mma na Fibrinolytic
Nattokinase nwere ike ịkwado mgbasa ọbara dị mma site n'inyere ahụ aka ịnọgide na-enwe nguzozi fibrin nkịtị na usoro mmebi nke mkpụkọ ọbara eke.
N'ime nyocha nke akpọrọ Nattokinase: Ihe Nnọchi Anya Ọgwụ Mgbochi Ọkpụkpụ Maka Mgbochi Ọrịa Obi, ndị nchọpụta kọwara nattokinase dị ka enzyme fibrinolytic nke nwere ike ịkwado obi na akwara. Nyocha ahụ na-akọwa na nattokinase nwere ike inye aka gbajie fibrin ozugbo ma nwee ike ịkwado sistemụ fibrinolytic nke ahụ site n'imetụta plasmin na ụzọ ndị ọzọ metụtara clot. Usoro ndị a na-egosi na nattokinase nwere ike ịrụ ọrụ n'ịkwado ọbara dị mma na ọrụ akwara.Weng et al., 2017).
Nyocha ọzọ, Nattokinase: Nhọrọ Na-ekwe Nkwa n'Igbochi na Ọgwụgwọ nke Ọrịa Obi, tụlere nattokinase dị ka otu n'ime ihe ndị kacha arụ ọrụ na natto. Ndị dere akwụkwọ ahụ gosipụtara mmetụta ya nwere ike inwe na fibrinolysis, ọbara mgbali elu, metabolism lipid, na ihe nrịbama metụtara atherosclerosis. Agbanyeghị, ha kwukwara na ọ dị mkpa ka e jiri ọmụmụ ihe mmadụ karịa iji kwado mkpa ya dị na ahụike, usoro ọgwụgwọ zuru oke, na nchekwa ogologo oge na ọtụtụ mmadụ dị iche iche (Chen et al., 2018).
2. Nwere ike inye aka mee ka ọbara mgbali elu dị mma
A mụọla Nattokinase maka ọrụ o nwere ike ịrụ n'ịkwado ọbara mgbali elu nkịtị, ọkachasị n'ime ndị nwere oke ọbara mgbali elu.
N'ime nnwale a na-eme n'enweghị usoro, nke a na-enyocha ugboro abụọ, nke a na-achịkwa placebo, ndị nchọpụta nyochachara ndị okenye 86 dị afọ 20 ruo 80 nwere ọbara mgbali systolic a na-agwọghị n'etiti 130 na 159 mmHg. Ndị sonyere natara nattokinase na 2,000 FU kwa ụbọchị ma ọ bụ placebo maka izu asatọ. Ndị sonyere iri asaa na atọ mechara ọmụmụ ihe ahụ. Ma e jiri ya tụnyere placebo, nattokinase jikọtara ya na mbelata na ọbara mgbali systolic na diastolic, yana mgbanwe dị n'etiti -5.55 mmHg na -2.84 mmHg, n'otu n'otu. Ọmụmụ ihe ahụ hụkwara mbelata na ọrụ renin plasma, na-atụ aro usoro enwere ike metụtara ịchịkwa ọbara mgbali (Kim et al., 2008).
N'ọmụmụ ihe ọzọ e mere n'ebe ugwu America nke a na-achịkwaghị achịkwa, nke a na-achịkwa site na placebo, mmadụ 79 so na ya nwere ọbara mgbali elu riri 100 mg nattokinase kwa ụbọchị ma ọ bụ placebo ruo izu asatọ. Ọmụmụ ihe ahụ lere anya na ọbara mgbali elu na ihe ndị metụtara ihe egwu obi, gụnyere von Willebrand factor. Nchọpụta ndị ahụ gosiri na oriri nattokinase nwere njikọ na mbelata ọbara mgbali elu na mbelata na von Willebrand factor, ihe nrịbama jikọtara ya na ahụike akwara na ọrụ mkpụkọ ọbara (Jensen et al., 2016).
Ọmụmụ ihe ndị a na-egosi na nattokinase nwere ike ịkwado nguzozi ọbara mgbali elu n'ime otu ụfọdụ. Agbanyeghị, ekwesighi iwere ya dị ka ihe nnọchi maka ọgwụ mgbochi ọbara mgbali elu ma ọ bụ nlekọta ahụike edepụtara.
3. Nwere ike ịkwado nguzozi ihe egwu obi
Nattokinase nwere ike inye aka kwado ahụike obi site n'imetụta ihe nrịbama ahọpụtara metụtara mkpụkọ ọbara, ọrụ arịa ọbara, na mgbasa ọbara.
Ọmụmụ ihe Jensen na ndị otu ya (2016) mere dị mkpa karịsịa n'ihi na ọ bụghị naanị na ọ nyochachara ọbara mgbali elu kamakwa ọ tụtara von Willebrand factor na platelet factor-4. Von Willebrand factor na-etinye aka na njikọta platelet na nhazi clot. Mbelata na akara a nwere ike igosi mmetụta nkwado na nguzozi akwara na ọbara. Agbanyeghị, nke a apụtaghị na nattokinase na-egbochi ihe omume obi, ebe ọ bụ na a chọrọ nnwale ụlọ ọgwụ buru ibu na ogologo iji kwado nsonaazụ ndị dị otú ahụ (Jensen et al., 2016).
Nyocha na meta-analysis nke afọ 2023 nke akpọrọ Nattokinase Supplementation and Cardiovascular Risk Factors tụlere nnwale ndị a na-achịkwa na-enweghị usoro na nattokinase na ihe nrịbama obi. Nyocha ahụ chọpụtara na mgbakwunye nattokinase nwere njikọ na mbelata dị nta na ọbara mgbali elu systolic na diastolic. Agbanyeghị, ndị dere akwụkwọ ahụ kwukwara na ihe akaebe maka ihe nrịbama ndị ọzọ, gụnyere nsonaazụ lipid na coagulation, adịchaghị agbanwe agbanwe n'ọmụmụ ihe niile (Li et al., 2023).
N'ozuzu, nattokinase nwere ike ịkwado ihe nrịbama obi ahọpụtara, mana mmetụta ya yiri ka ọ dabere na ọnụọgụgụ ndị a na-amụ, dose, nhazi ngwaahịa, na oge ojiji.
4. Nwere ike inye aka kwado metabolism abụba na ahụike akwara
Ụfọdụ nnyocha na-egosi na nattokinase nwere ike ịkwado metabolism lipid na ahụike akwara, mana ihe akaebe ahụ ekwenyeghị kpamkpam.
N'ọmụmụ ihe gbasara akwara carotid atherosclerosis na hyperlipidemia, a nyochachara nattokinase supplementation maka mmetụta ya na ọkpụrụkpụ carotid intima-media, nha plaque, na profaịlụ lipid. Nchọpụta ahụ gosiri na nattokinase nwere ike ibelata nha plaque ma melite ụfọdụ akara lipid na ndị sonyere na atherosclerosis na lipids dị elu (Ren et al., 2017).
Nnyocha e mere n'oge na-adịbeghị anya lere anya na ọgwụ nattokinase dị elu kwa ụbọchị, 10,800 FU kwa ụbọchị, n'ihe gbasara ọganihu atherosclerosis na hyperlipidemia. Ndị nchọpụta ahụ kọrọ na ọgwụ a nwere njikọ na mmụba na profaịlụ lipid na usoro metụtara atherosclerosis. Agbanyeghị, ekwesighi ịkọwapụta nsonaazụ dị elu na ngwaahịa nattokinase niile ma ọ bụ usoro mgbakwunye ọkọlọtọ na-enweghị nyocha nke ọma (Chen et al., 2022).
N'otu oge ahụ, ọ bụghị ọmụmụ ihe niile egosila nsonaazụ dị mma. Ọmụmụ Ihe Mgbochi Nattokinase Atherothrombotic, nnwale a na-achịkwa n'usoro n'ime ndị nwere ahụike nwere obere ihe egwu obi, chọpụtara na mgbakwunye nattokinase emetụtaghị ọganihu atherosclerosis dị ala, ọbara mgbali elu, ma ọ bụ ihe nrịbama ụlọ nyocha mgbe oge ọgwụgwọ nke afọ 3 gasịrị (Hodis na ndị otu ya, 2021).
Ntụnyere a na-egosi na nattokinase nwere ike ịdị mkpa karịa n'etiti ndị a họọrọ, ọkachasị ndị nwere ihe egwu obi kpọmkwem, kama ndị nwere ahụike dị ala.
5. Nwere ike inye nkwado dịka akụkụ nke usoro ahụike obi
Mgbe ụfọdụ, a na-amụ Nattokinase yana ihe ndị ọzọ bara uru, ọkachasị na nchọpụta ahụike cardiometabolic.
N'ime nnwale emere n'afọ 2024, nke a na-achịkwa site na placebo, ndị nchọpụta nyochara nattokinase yana osikapa yist uhie n'ahụ ndị ọrịa nwere ọrịa akwara obi kwụsiri ike. Ọmụmụ ihe ahụ lere anya na mmetụta lipid-lowering, antihypertensive, na antithrombotic. Nsonaazụ ya gosiri na njikọta ahụ nwere ike imeziwanye ụfọdụ paramita cardiometabolic, ọ bụ ezie na ọ dị mkpa ịmara na nke a bụ ọmụmụ ihe ejikọtara ọnụ. Ya mere, uru ndị a enweghị ike ikwu na ọ bụ naanị nattokinase (Liu et al., 2024).
Ụdị nnyocha a dị mkpa n'ihi na ọtụtụ ihe na-emetụta ahụike obi, gụnyere nri, mmega ahụ, ọkwa lipid, ọbara mgbali elu, mbufụt, nrụgide oxidative, na mkpụrụ ndụ ihe nketa. Nattokinase nwere ike ịba uru n'ime atụmatụ ahụike sara mbara, mana ekwesịrị itinye ya dị ka ihe na-akwado ya kama ịbụ ihe ngwọta nkeonwe.
6. A na-anabata ya nke ọma n'ozuzu ya, mana ọ dị mkpa ka a na-elekọta ya nke ọma.
O yiri ka a na-anabata Nattokinase nke ọma n'ọtụtụ nnyocha mmadụ mere, mana ọ chọrọ iji ya mee ihe n'ụzọ kwesịrị ekwesị n'ihi mmetụta ọ nwere ike inwe na usoro mkpụkọ ọbara.
Nnyocha ahụike emere n'ezie nyochachara nattokinase na 100 mg kwa ụbọchị n'ime ndị ọrịa a nabatara ịwa ahụ akwara. Ndị nchọpụta ahụ kọrọ ihe ndị a hụrụ na-akwado nchekwa nke ojiji nattokinase n'ọnọdụ a, ọ bụ ezie na nlekọta ahụike nke onye ọ bụla ka dị mkpa, ọkachasị maka ndị na-aṅụ ọgwụ anticoagulant ma ọ bụ antiplatelet (Gallelli na ndị otu ya, 2021).
Ebe ọ bụ na nattokinase nwere ike imetụta fibrinolysis na ihe nrịbama metụtara klọọkụ, ọ nwere ike ọ gaghị adabara onye ọ bụla. Ndị na-aṅụ ọgwụ ndị na-ebelata ọbara, aspirin, ọgwụ mgbochi ọbara, ma ọ bụ ọgwụ antiplatelet, yana ndị nwere nsogbu ọbara ọgbụgba, ịwa ahụ na-abịa, afọ ime, ma ọ bụ nsogbu ahụike siri ike, kwesịrị ịchọ ndụmọdụ ahụike tupu ha ejiri nattokinase.
Nattokinase bụ enzyme pụrụ iche nke sitere na soybean a kpụchara akpụcha, a makwaara ya nke ọma maka ọrụ ọ na-arụ n'ịkwado ahụike obi na ọbara. Akụkụ nyocha kachasị sie ike gụnyere:
- Nkwado ọbara dị mma
- Ọrụ Fibrinolytic
- Ọbara mgbali elu itule
- Nkwado ihe nrịbama akwara
- Metabolism lipid na ahụike akwara na ndị mmadụ ahọpụtara
Nnyocha dịnụ na-enye obi ụtọ, mana ọ bụghị nke zuru oke. Ụfọdụ nnyocha na-egosi mmụba dị mkpa na ọbara mgbali elu, ọrụ fibrinolytic, na ihe nrịbama obi, ebe ndị ọzọ na-egosi obere ma ọ bụ enweghị mmetụta ọ bụla, ọkachasị n'ime ndị nwere ahụike dị ala. Nke a na-egosi na nattokinase nwere ike ịrụ ọrụ dị iche iche dabere na ọnọdụ ahụike nke onye ọ bụla, dose, oge, na ịdị mma nke ngwaahịa ahụ.
A ga-ele Nattokinase anya dị ka ihe na-enyere aka na-arụ ọrụ kama ịgwọ ma ọ bụ gwọọ ya. Ọ bụrụ na ejiri ya nke ọma, ọ nwere ike ịbụ mgbakwunye bara uru na usoro ahụike obi, ọkachasị ndị lekwasịrị anya na mgbasa ọbara, ịka nká dị mma, na nguzozi metabolic.
Disclaimer: EFSA, KFDA ma ọ bụ FDA enyochabeghị nkwupụta a. Emeghị ka ngwaahịa a chọpụta, gwọọ, gwọọ, ma ọ bụ gbochie ọrịa ọ bụla. Ọ bụ ezie na ozi enyere dabere na ntụaka a pụrụ ịtụkwasị obi, anyị anaghị ekwu ma ọ bụ nkwa ọ bụla. Ọ dị mkpa ka ị gakwuru onye ndụmọdụ ahụike gị maka ndụmọdụ na nduzi nkeonwe metụtara ahụike gị.
References
- Chen, H., McGowan, EM, Ren, N., Lal, S., Nassif, N., Shad-Kaneez, F., Qu, X. na Lin, Y., 2018. Nattokinase: Nhọrọ ọzọ na-ekwe nkwa n'igbochi na ọgwụgwọ nke ọrịa obi. Ntụle biomarker, 13, peeji 1–8 .
- Chen, H., McGowan, EM, Ren, N., Lal, S., Nassif, N., Shad-Kaneez, F., Qu, X. na Lin, Y., 2022. Nlekọta dị irè nke ọganihu atherosclerosis na hyperlipidemia na nattokinase. Oke na ọgwụ obi obi.
- Gallelli, G., Cione, E., Caroleo, MC, Carullo, G., Genchi, G., Rende, P. na Citraro, R., 2021. Data e dekọrọ n'ezie na-akwado nchekwa nke nattokinase n'ime ndị ọrịa nwere ọrịa akwara. Nri, 13 (6), p.2031.
- Hodis, HN, Mack, WJ, Dustin, L., Mahrer, PR na Azen, SP, 2021. Ọmụmụ ihe mgbochi Nattokinase atherothrombotic: Nnwale a na-achịkwa n'usoro. Ọgwụ gbasara ọbara na microcirculation, 78(4), pp.339–353.
- Jensen, GS, Lenninger, M., Ero, MP na Benson, KF, 2016. Oriri nattokinase na-ejikọta ya na mbelata ọbara mgbali elu na ihe na-akpata von Willebrand, ihe na-egosi ihe egwu obi: Nsonaazụ sitere na nnwale ahụike North America nke a na-achịkwa nke ọma, nke a na-achịkwa nke ọma, nke nwere ọtụtụ etiti. Njikwa Nrụgide Ọbara Agbakwunyere, 9, peeji 95–104 .
- Kim, JY, Gum, SN, Paik, JK, Lim, HH, Kim, KC, Ogasawara, K., Inoue, K., Park, S., Jang, Y. na Lee, JH, 2008. Mmetụta nke nattokinase na ọbara mgbali elu: Nnwale a na-achịkwaghị achịkwa. Nnyocha ọbara mgbali elu, 31(8), pp.1583–1588.
- Li, X., Zheng, X., Liu, Y. na Zhang, Y., 2023. Ntinye Nattokinase na ihe ndị nwere ike ibute ọrịa obi: Nyocha usoro na nyocha meta. Nlebanya na ọgwụ obi, 24 (8), p.234.
- Liu, M., Zhang, H., Wang, Y., Li, X. na Chen, J., 2024. Mmetụta nattokinase na-ebelata abụba, mgbochi ọbara mgbali elu, na mgbochi thrombotic nke nattokinase jikọtara ya na osikapa yist uhie n'ime ndị ọrịa nwere ọrịa akwara obi kwụsiri ike: Nnwale a na-achịkwaghị achịkwa, nke a na-ekpuchi ihu abụọ, nke a na-achịkwa site na placebo. N'ihu Nri.
- Ren, NN, Chen, HJ, Li, Y., McGowan, E. na Lin, YG, 2017. Ọmụmụ ihe gbasara mmetụta nke nattokinase na akwara carotid atherosclerosis na hyperlipidaemia. Zhonghua Yi Xue Za Zhi, 97(26), pp.2038–2042.
- Weng, Y., Yao, J., Sparks, S. na Wang, KY, 2017. Nattokinase: Ọgwụ mgbochi thrombosis n'ọnụ maka igbochi ọrịa obi. Akwụkwọ bụ International Journal of Scholarships, 18 (3), p.523.
