Qee cov tshuaj uas tau tshawb fawb tshaj plaws hauv kev tshawb fawb txog nutraceutical, txij li curcumin mus rau CoQ10 mus rau vitamin C, muaj ib qho teeb meem sib xws: coj lawv mus rau hauv cov ntshav hauv qhov ntau thiab tsawg. Liposomal delivery yog ib qho ntawm cov thev naus laus zis uas siv los daws qhov teeb meem no, thiab nws yog kev tshawb fawb tom qab NaturMed Scientific's LipoXbio™ platform.
Vim Li Cas Hom Ntawv Xa Khoom Thiaj Tseem Ceeb Ib Yam Li Cov Khoom Xyaw Nws Tus Kheej
Ib yam khoom noj ntxiv tsuas yog muaj txiaj ntsig zoo li qhov ntau ntawm cov tshuaj uas mus txog cov ntshav xwb. Muaj ntau yam khoom noj muaj txiaj ntsig thiab cov nroj tsuag uas raug rhuav tshem los ntawm cov kua qaub hauv plab thiab cov enzymes zom zaub mov ua ntej lawv tuaj yeem nqus tau, lossis lawv tsuas yog tsis yaj zoo txaus hauv plab kom hla mus rau hauv cov ntshav hauv qhov ntau thiab tsawg. Qhov no muaj tseeb txawm tias rau cov khoom xyaw uas tau tsim zoo thiab tau kawm zoo; cov tshuaj nws tus kheej yuav zoo, tab sis hom ntawv uas nws xa tuaj yeem txwv tsis pub lub cev siv nws ntau npaum li cas.
Liposome yog dab tsi tiag tiag
Ib lub liposome yog ib lub qauv me me, kheej kheej uas tsim los ntawm phospholipids, tib chav kawm ntawm cov rog molecules uas ua rau daim nyias nyias ntawm txhua lub cell hauv tib neeg lub cev. Vim yog qhov zoo sib xws ntawm cov qauv no, liposomes feem ntau raug zam zoo los ntawm lub cev zom zaub mov thiab muaj peev xwm encapsulate ib qho khoom xyaw nquag hauv ib txheej tiv thaiv bilayer. Qhov no tseem ceeb rau ob qho laj thawj: lub plhaub phospholipid tuaj yeem tiv thaiv cov tshuaj rhiab heev los ntawm kev puas tsuaj thaum lawv hla dhau lub plab thiab txoj hnyuv, thiab vim tias lub plhaub zoo li lub cell membrane ntuj, nws tuaj yeem txhawb nqa kev nqus tau zoo dua ntawm phab ntsa plab hnyuv piv rau cov khoom xyaw tsis muaj kev tiv thaiv (Chen et al., 2024).
Cov liposomes kuj tsis tshua muaj vim lawv tuaj yeem nqa cov tshuaj uas yaj tau hauv dej thiab cov tshuaj uas yaj tau hauv roj hauv tib lub qauv, cov molecules uas yaj tau hauv dej hauv lub plawv dej, cov molecules uas yaj tau hauv roj hauv cov lipid bilayer nws tus kheej. Qhov kev hloov pauv no yog ib feem ntawm vim li cas cov thev naus laus zis tau raug tshawb nrhiav thoob plaws ntau yam khoom xyaw nquag, los ntawm cov vitamins thiab cov zaub mov mus rau cov tshuaj ntsuab.
Cov Kev Tshawb Fawb Qhia Txog Dab Tsi
Cov pov thawj tseeb tshaj plaws rau kev xa khoom liposomal feem ntau yog los ntawm kev tshawb fawb txog kev noj qab haus huv ntawm lub cev, piv rau daim ntawv liposomal ntawm cov khoom xyaw nrog nws tus qauv, tsis muaj capsulated sib npaug. Hauv ib qho kev sim randomized, ob chav dig muag, placebo-tswj crossover, ib daim ntawv liposomal vitamin C tsim tau 27% siab dua qhov siab tshaj plaws hauv cov ntshav thiab 20% siab dua qhov siab tshaj plaws hauv cov leukocytes (ib hom qe ntshav dawb cuam tshuam rau kev ua haujlwm ntawm lub cev tiv thaiv kab mob) piv rau tus qauv, tsis yog liposomal vitamin C ntawm tib koob tshuaj (Purpura et al., 2024). Vim tias cov leukocytes vam khom ascorbate rau ntau yam ntawm lawv cov haujlwm, hom kev nqus ntawm qib cellular no suav hais tias yog lub cim tseem ceeb dua li cov qib plasma ib leeg.
Nws tsim nyog ua kom meej txog qhov pov thawj no ua thiab tsis qhia dab tsi. Kev txhim kho bioavailability feem ntau yog tshaj tawm ntawm ib qho khoom xyaw, ib qho kev tsim khoom es tsis yog ua ib qho kev sib npaug ruaj khov, thoob ntiaj teb uas siv rau txhua yam khoom xyaw uas muab tso rau hauv liposome. Qhov loj ntawm cov txiaj ntsig nyob ntawm cov khoom xyaw tshwj xeeb, qhov loj me thiab cov khoom sib xyaw ntawm liposome, thiab yuav ua li cas cov qauv tsim thiab ruaj khov.
LipoXbio™: NaturMed Scientific lub Platform xa khoom
LipoXbio™ yog NaturMed Scientific lub platform tsim cov tshuaj liposomal uas tau tsim los siv cov kev tshawb fawb no thoob plaws lub tuam txhab cov khoom xyaw dav dua li khi rau ib qho tshuaj xwb. LipoXbio™ daws qhov teeb meem no los ntawm kev encapsulation thiab kev tiv thaiv, muab lwm txoj hauv kev rau cov neeg tsim cov tshuaj rau tib lub hom phiaj tseem ceeb: kom tau txais ntau yam khoom xyaw nquag mus rau qhov chaw uas nws xav tau mus rau hauv lub cev.
Hauv kev xyaum, qhov no txhais tau tias LipoXbio™-raws li cov qauv tau tsim los rau:
- Tiv thaiv cov khoom siv rhiab heev los ntawm kev rhuav tshem los ntawm cov kua qaub hauv plab thiab cov enzymes zom zaub mov ua ntej kev nqus tuaj yeem tshwm sim.
- Txhawb kev xa khoom ntawm cov khoom xyaw uas yaj hauv dej thiab roj, ua kom dav dua ntawm ntau yam khoom sib xyaw uas ib hom ntawv xa khoom tuaj yeem ua tau.
- Txhim kho kev ruaj khov ntawm cov mis, uas tseem ceeb rau cov khoom xyaw uas lwm yam yooj yim rau oxidation lossis degradation thaum lub sijhawm txee.
- Pab kom cov koob tshuaj tsawg dua zoo rau cov khoom xyaw uas qhov kev nyab xeeb ntawm lub cev yog qhov txwv, uas tuaj yeem txhawb nqa kev tsim cov tshuaj ntsiav, hmoov, thiab cov kua dej xws li cov dej haus ua haujlwm thiab cov tshuaj txhaj.
Cov Ntsiab Lus thiab Kev Txwv
Kev xa khoom liposomal yog ib qho chaw tsim kho zoo ntawm kev tshawb fawb txog tshuaj thiab nutraceutical, tab sis nws tsis yog qhov lav tias yuav muaj txiaj ntsig zoo dua rau txhua yam khoom xyaw. Qee cov khoom xyaw twb tau nqus tau zoo hauv lawv daim ntawv tus qauv thiab tau txais me ntsis los ntawm encapsulation, thaum lwm tus xav tau qhov loj me lossis cov khoom sib xyaw tshwj xeeb kom pom qhov txiaj ntsig tseem ceeb. Kev tsim khoom kuj tseem ceeb heev: cov liposome tsis zoo lossis tsis ruaj khov tuaj yeem poob nws cov qauv tiv thaiv ua ntej mus txog txoj hnyuv me, txo cov txiaj ntsig ntawm cov thev naus laus zis rau pawg ntawd. Ib yam li txhua yam thev naus laus zis xa khoom, qhov teeb meem rau kev siv nws yog qhov muaj zog tshaj plaws thaum nws raug soj ntsuam cov khoom xyaw los ntawm cov khoom xyaw, es tsis txhob xav tias yog kev txhim kho thoob ntiaj teb.
Lus Cim: Cov khoom xyaw uas tau tham hauv tsab xov xwm no yog cov khoom xyaw ntxiv rau cov khoom noj, tsis yog cov tshuaj uas tau tso cai, thiab tsis yog siv los kuaj mob, kho, kho kom zoo, lossis tiv thaiv kab mob. Cov neeg siv khoom uas muaj mob ua ntej lossis cov neeg uas noj tshuaj raug qhia kom sab laj nrog tus kws kho mob ua ntej siv.
References
Chen, J., Hu, S., Sun, M., Shi, J., Zhang, H., Yu, H. thiab Yang, Z. (2024) 'Cov kev nce qib tsis ntev los no thiab kev txhais lus hauv kev kho mob ntawm cov kab ke xa khoom liposomal hauv kev kho mob qog noj ntshav', European Journal of Pharmaceutical Sciences , 193, tsab xov xwm 106688. Muaj nyob rau ntawm: https://doi.org/10.1016/j.ejps.2023.106688
Purpura, M., Jäger, R., Godavarthi, A., Bhaskarachar, D. thiab Tinsley, GM (2024) 'Kev xa khoom liposomal ua rau kev nqus ntawm vitamin C mus rau hauv cov ntshav thiab cov leukocytes: kev sim ob zaug, tswj placebo, randomized', European Journal of Nutrition , 63(8), pp. 3037–3046. Muaj nyob rau ntawm: https://doi.org/10.1007/s00394-024-03487-8
Lus Ceeb Toom: EFSA, KFDA lossis FDA tsis tau soj ntsuam cov lus qhia no. Cov khoom no tsis yog siv los kuaj mob, kho, kho kom zoo, lossis tiv thaiv kab mob. Txawm hais tias cov ntaub ntawv muab los ntawm cov ntaub ntawv pov thawj ntseeg tau, peb tsis ua cov lus thov lossis kev lav phib xaub tshwj xeeb. Nws yog ib qho tseem ceeb uas yuav tsum sab laj nrog koj tus kws pab tswv yim kev noj qab haus huv kom tau txais cov lus qhia thiab kev taw qhia txog koj txoj kev noj qab haus huv.
