Nattokinase yog ib qho enzyme uas muaj nyob hauv ntuj tsim los ntawm natto, ib yam khoom noj Nyiv Pooj uas ua los ntawm kev siv cov taum pauv nrog Bacillus subtilis natto ua kom cov ntshav khov. Nws tau txais kev txaus siab los ntawm kev tshawb fawb vim nws lub luag haujlwm tseem ceeb hauv kev txhawb nqa kev noj qab haus huv ntawm lub plawv, kev ntws ntshav kom zoo, thiab kev ncig ntshav kom zoo. Nattokinase paub tshwj xeeb rau nws cov haujlwm fibrinolytic, uas txhais tau tias nws yuav pab txhawb nqa lub cev txoj kev zom cov fibrin, ib qho protein uas koom nrog kev tsim cov ntshav txhaws.
Tsis zoo li ntau yam khoom xyaw botanical, nattokinase yog ib qho khoom xyaw ua haujlwm raws li enzyme. Nws tau raug kawm txog nws cov teebmeem rau ntshav siab, ntshav viscosity, cov cim qhia txog kev txhaws, lipid metabolism, thiab kev noj qab haus huv ntawm cov hlab ntsha. Txawm li cas los xij, cov pov thawj muaj tseem tab tom tsim, thiab cov txiaj ntsig sib txawv nyob ntawm qhov ntau npaum li cas, kev tsim qauv kev tshawb fawb, cov pej xeem, thiab lub sijhawm. Hauv qab no yog qee qhov txiaj ntsig kev noj qab haus huv ntawm nattokinase raws li kev tshawb fawb.
1. Txhawb nqa kev ntws ntshav zoo thiab kev ua haujlwm fibrinolytic
Nattokinase tej zaum yuav txhawb nqa kev ncig ntshav kom zoo los ntawm kev pab lub cev tswj hwm qhov sib npaug ntawm fibrin thiab cov txheej txheem ua kom cov ntshav khov.
Hauv kev tshuaj xyuas hu ua Nattokinase: Ib qho tshuaj Antithrombotic hauv qhov ncauj rau kev tiv thaiv kab mob plawv, cov kws tshawb fawb tau piav qhia txog nattokinase ua ib qho enzyme fibrinolytic nrog cov khoom muaj peev xwm txhawb nqa lub plawv. Kev tshuaj xyuas piav qhia tias nattokinase tuaj yeem pab rhuav tshem fibrin ncaj qha thiab kuj tseem tuaj yeem txhawb nqa lub cev lub cev fibrinolytic los ntawm kev cuam tshuam rau plasmin thiab lwm txoj hauv kev ntsig txog cov ntshav txhaws. Cov txheej txheem no qhia tias nattokinase tuaj yeem ua lub luag haujlwm hauv kev txhawb nqa cov ntshav ntws zoo thiab kev ua haujlwm ntawm cov hlab ntsha (Weng thiab al., 2017).
Lwm qhov kev tshuaj xyuas, Nattokinase: Ib Txoj Kev Xaiv Zoo Hauv Kev Tiv Thaiv thiab Kho Mob Kab Mob Plawv, tau tham txog nattokinase ua ib qho ntawm cov khoom xyaw nquag tshaj plaws ntawm natto. Cov kws sau ntawv tau hais txog nws cov teebmeem rau fibrinolysis, ntshav siab, lipid metabolism, thiab atherosclerosis-cuam tshuam cov cim. Txawm li cas los xij, lawv kuj tau sau tseg tias xav tau kev tshawb fawb ntxiv rau tib neeg kom paub meej tias nws muaj feem cuam tshuam rau kev kho mob, kev noj tshuaj zoo tagnrho, thiab kev nyab xeeb mus sij hawm ntev hauv cov pej xeem sib txawv (Chen et al., 2018).
2. Tej zaum yuav pab tswj tau ntshav siab kom zoo
Nattokinase tau raug kawm txog nws lub luag haujlwm hauv kev txhawb nqa cov ntshav siab, tshwj xeeb tshaj yog rau cov neeg uas muaj ntshav siab.
Hauv kev sim tshuaj randomized, ob chav dig muag, thiab tshuaj placebo, cov kws tshawb fawb tau kawm 86 tus neeg laus hnub nyoog 20 txog 80 xyoo uas tsis tau kho ntshav siab systolic ntawm 130 thiab 159 mmHg. Cov neeg koom nrog tau txais nattokinase ntawm 2,000 FU ib hnub lossis tshuaj placebo rau 8 lub lis piam. Xya caum peb tus neeg koom nrog ua tiav kev tshawb fawb. Piv nrog cov tshuaj placebo, nattokinase tau cuam tshuam nrog kev txo qis ntshav siab systolic thiab diastolic, nrog rau kev hloov pauv ntawm kwv yees li -5.55 mmHg thiab -2.84 mmHg, raws li. Kev tshawb fawb kuj tau pom tias muaj kev txo qis hauv plasma renin kev ua haujlwm, qhia txog ib qho ua tau ntawm cov txheej txheem ntsig txog kev tswj ntshav siab (Kim et al., 2008).
Hauv lwm txoj kev tshawb fawb hauv North America uas tau muab faib ua ob pawg, uas yog ob hom dig muag, thiab tswj los ntawm placebo, muaj 79 tus neeg koom nrog uas muaj ntshav siab tau noj 100 mg nattokinase txhua hnub lossis placebo rau 8 lub lis piam. Txoj kev tshawb fawb no tau tshuaj xyuas cov cim qhia txog kev ntshav siab thiab cov cim qhia txog kev pheej hmoo ntawm lub plawv, suav nrog von Willebrand factor. Cov kev tshawb pom tau hais tias kev noj nattokinase muaj feem cuam tshuam nrog kev txo cov ntshav siab thiab kev txo qis ntawm von Willebrand factor, uas yog ib qho cim qhia txog kev noj qab haus huv ntawm cov hlab ntsha thiab kev ua haujlwm ntawm cov ntshav txhaws (Jensen li al., 2016).
Cov kev tshawb fawb no qhia tias nattokinase yuav pab txhawb kev sib npaug ntawm cov ntshav siab hauv qee pawg. Txawm li cas los xij, nws yuav tsum tsis txhob raug suav hais tias yog ib qho kev hloov pauv rau cov tshuaj tiv thaiv ntshav siab lossis kev kho mob.
3. Tej zaum yuav txhawb nqa qhov sib npaug ntawm cov cim qhia txog kev pheej hmoo ntawm lub plawv
Nattokinase tuaj yeem pab txhawb kev noj qab haus huv ntawm lub plawv los ntawm kev cuam tshuam cov cim qhia tshwj xeeb ntsig txog kev txhaws ntshav, kev ua haujlwm ntawm cov hlab ntsha, thiab kev ncig ntshav.
Txoj kev tshawb fawb los ntawm Jensen et al. (2016) yog qhov tseem ceeb tshaj plaws vim tias nws tsis yog tsuas yog tshuaj xyuas cov ntshav siab xwb tab sis kuj ntsuas von Willebrand factor thiab platelet factor-4. Von Willebrand factor muaj feem cuam tshuam rau platelet adhesion thiab clotting. Kev txo qis ntawm cov cim no yuav qhia txog kev txhawb nqa rau kev sib npaug ntawm cov hlab ntsha thiab cov ntshav ncig. Txawm li cas los xij, qhov no tsis tau txhais hais tias nattokinase tiv thaiv cov teeb meem plawv, vim tias kev sim tshuaj loj dua thiab ntev dua yuav tsum tau ua kom paub meej cov txiaj ntsig zoo li no (Jensen li al., 2016).
Xyoo 2023 kev tshuaj xyuas thiab kev tshuaj xyuas meta-analysis hu ua Nattokinase Supplementation thiab Cardiovascular Risk Factors tau soj ntsuam cov kev sim tshuaj ntsuam xyuas ntawm nattokinase thiab cov cim qhia txog kev mob plawv. Kev tshuaj xyuas pom tias nattokinase supplementation cuam tshuam nrog kev txo qis me ntsis ntawm systolic thiab diastolic ntshav siab. Txawm li cas los xij, cov kws sau ntawv kuj tau sau tseg tias cov pov thawj rau lwm cov cim, suav nrog cov lipid thiab coagulation cov txiaj ntsig, tsis sib xws thoob plaws kev tshawb fawb (Li li al., 2023).
Zuag qhia tag nrho, nattokinase yuav txhawb nqa cov cim qhia txog kev mob plawv, tab sis nws cov teebmeem zoo li nyob ntawm cov pejxeem kawm, koob tshuaj, kev tsim khoom, thiab lub sijhawm siv.
4. Tej zaum yuav pab txhawb nqa Lipid Metabolism thiab Arterial Health
Qee qhov kev tshawb fawb qhia tias nattokinase yuav txhawb nqa cov metabolism lipid thiab kev noj qab haus huv ntawm cov hlab ntsha, tab sis cov pov thawj tsis sib xws tag nrho.
Hauv kev tshawb fawb txog carotid artery atherosclerosis thiab hyperlipidemia, nattokinase supplementation tau tshawb nrhiav txog nws cov nyhuv rau carotid intima-media thickness, plaque loj, thiab lipid profile. Cov kev tshawb pom tau hais tias nattokinase tuaj yeem txo cov kev ntsuas ntsig txog plaque thiab txhim kho qee cov cim lipid hauv cov neeg koom nrog uas muaj atherosclerosis thiab cov lipids siab (Ren thiab lwm tus, 2017).
Ib txoj kev tshawb fawb tom qab tau tshuaj xyuas qhov ntau dua ntawm nattokinase txhua hnub, 10,800 FU ib hnub, hais txog kev nce qib ntawm atherosclerosis thiab hyperlipidemia. Cov kws tshawb fawb tau tshaj tawm tias qhov koob tshuaj no cuam tshuam nrog kev txhim kho hauv cov lipid profile thiab cov kev ntsuas ntsig txog atherosclerosis. Txawm li cas los xij, cov kev tshawb pom ntau ntawm cov tshuaj yuav tsum tsis txhob suav nrog rau txhua yam khoom nattokinase lossis cov koob tshuaj ntxiv yam tsis muaj kev soj ntsuam zoo (Chen et al., 2022).
Tib lub sijhawm, tsis yog txhua txoj kev tshawb fawb tau pom cov txiaj ntsig zoo. Kev Tshawb Fawb Txog Kev Tiv Thaiv Kab Mob Atherothrombotic Nattokinase, kev sim tshuaj randomized hauv cov tib neeg noj qab haus huv uas muaj kev pheej hmoo tsawg ntawm kev mob plawv, pom tias kev noj nattokinase tsis cuam tshuam rau qhov kev nce qib ntawm cov kab mob atherosclerosis subclinical, ntshav siab, lossis cov cim hauv chaw kuaj mob tom qab lub sijhawm kho mob nruab nrab ntawm 3 xyoos (Hodis thiab lwm tus, 2021).
Qhov kev sib piv no qhia tau hais tias nattokinase tej zaum yuav muaj feem cuam tshuam ntau dua rau cov pej xeem xaiv, tshwj xeeb tshaj yog cov neeg uas muaj cov yam ntxwv tshwj xeeb ntawm kev pheej hmoo ntawm lub plawv, es tsis yog cov neeg noj qab haus huv uas muaj kev pheej hmoo tsawg.
5. Tej zaum yuav muab kev txhawb nqa ua ib feem ntawm Txoj Kev Noj Qab Haus Huv Cardiometabolic
Nattokinase qee zaum raug kawm ua ke nrog lwm cov khoom xyaw ua haujlwm, tshwj xeeb tshaj yog hauv kev tshawb fawb txog kev noj qab haus huv cardiometabolic.
Xyoo 2024, kev sim tshuaj uas tau muab faib ua ob pawg, thiab kev sim tshuaj placebo, cov kws tshawb fawb tau kawm txog nattokinase ua ke nrog cov mov paj liab hauv cov neeg mob uas muaj kab mob plawv ruaj khov. Kev tshawb fawb tau tshawb nrhiav cov teebmeem txo cov roj lipid, txo cov ntshav siab, thiab tiv thaiv cov ntshav txhaws. Cov txiaj ntsig tau qhia tias kev sib xyaw ua ke no yuav txhim kho qee yam kev ntsuas cardiometabolic, txawm hais tias nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias qhov no yog kev tshawb fawb sib xyaw ua ke. Yog li ntawd, cov txiaj ntsig tsis tuaj yeem raug suav hais tias yog nattokinase ib leeg xwb (Liu li al., 2024).
Hom kev tshawb fawb no tseem ceeb heev vim tias kev noj qab haus huv ntawm lub plawv thiab cov hlab ntsha raug cuam tshuam los ntawm ntau yam, suav nrog kev noj zaub mov, kev ua ub ua no, cov roj lipid, ntshav siab, kev o, kev ntxhov siab oxidative, thiab noob caj noob ces. Nattokinase tej zaum yuav haum rau hauv txoj kev npaj noj qab haus huv dav dua, tab sis nws yuav tsum tau muab tso ua ib qho khoom xyaw txhawb nqa es tsis yog ib qho kev daws teeb meem uas sawv cev.
6. Feem ntau zam tau zoo, tab sis yuav tsum tau saib xyuas
Nattokinase zoo li feem ntau raug zam tau zoo hauv ntau qhov kev tshawb fawb tib neeg, tab sis nws yuav tsum tau siv lub luag haujlwm vim nws muaj peev xwm ua rau cov ntshav txhaws.
Ib txoj kev tshawb fawb hauv lub neej tiag tiag tau soj ntsuam nattokinase ntawm 100 mg ib hnub rau cov neeg mob uas tau txais kev phais vascular. Cov kws tshawb fawb tau tshaj tawm cov kev soj ntsuam txhawb nqa kev nyab xeeb ntawm kev siv nattokinase hauv qhov chaw no, txawm hais tias kev saib xyuas tus kheej tseem ceeb, tshwj xeeb tshaj yog rau cov neeg noj tshuaj anticoagulant lossis antiplatelet (Gallelli thiab lwm tus, 2021).
Vim tias nattokinase yuav cuam tshuam rau fibrinolysis thiab cov cim qhia txog kev ntshav txhaws, nws yuav tsis haum rau txhua tus. Cov neeg noj cov tshuaj thinning ntshav, aspirin, anticoagulants, lossis antiplatelet tshuaj, nrog rau cov neeg uas muaj teeb meem ntshav, phais mob tom ntej, cev xeeb tub, lossis mob hnyav, yuav tsum nrhiav kev pab kho mob ua ntej siv nattokinase.
Nattokinase yog ib qho enzyme tshwj xeeb uas tau los ntawm cov taum pauv fermented thiab paub zoo tshaj plaws rau nws lub luag haujlwm hauv kev txhawb nqa kev noj qab haus huv ntawm lub plawv thiab cov ntshav ncig. Nws cov kev tshawb fawb zoo tshaj plaws suav nrog:
- Kev txhawb nqa cov ntshav ntws zoo
- Kev ua haujlwm ntawm fibrinolytic
- Ntshav siab sib npaug
- Kev txhawb nqa cov cim qhia txog cov hlab ntsha
- Kev hloov pauv ntawm cov roj lipid thiab kev noj qab haus huv ntawm cov hlab ntsha hauv cov pej xeem xaiv
Cov kev tshawb fawb muaj nyob rau hauv no zoo heev, tab sis tsis yog qhov sib xws kiag li. Qee qhov kev tshawb fawb qhia txog kev txhim kho tseem ceeb hauv cov ntshav siab, kev ua haujlwm fibrinolytic, thiab cov cim qhia txog kev mob plawv, thaum lwm tus qhia txog kev cuam tshuam tsawg lossis tsis muaj txiaj ntsig, tshwj xeeb tshaj yog rau cov neeg noj qab haus huv uas muaj kev pheej hmoo tsawg. Qhov no qhia tau hais tias nattokinase yuav ua haujlwm sib txawv nyob ntawm tus kheej txoj kev noj qab haus huv, koob tshuaj, lub sijhawm, thiab qhov zoo ntawm cov khoom.
Nattokinase yuav tsum raug saib ua ib yam khoom xyaw uas txhawb nqa kev ua haujlwm ntau dua li kev kho mob lossis kev kho mob. Thaum siv kom raug, nws yuav yog ib qho khoom muaj nqis ntxiv rau cov tshuaj noj qab haus huv ntawm lub plawv, tshwj xeeb tshaj yog cov uas tsom mus rau kev ncig ntshav, kev laus zoo, thiab kev sib npaug ntawm cov metabolism.
Disclaimer: Cov lus qhia no tsis tau raug soj ntsuam los ntawm EFSA, KFDA lossis FDA. Cov khoom no tsis yog siv los kuaj mob, kho, kho kom zoo, lossis tiv thaiv kab mob. Txawm hais tias cov ntaub ntawv muab los ntawm cov ntaub ntawv pov thawj ntseeg tau, peb tsis ua cov lus thov lossis kev lav phib xaub tshwj xeeb. Nws yog ib qho tseem ceeb uas yuav tsum sab laj nrog koj tus kws pab tswv yim kev noj qab haus huv kom tau txais cov lus qhia thiab kev taw qhia txog koj txoj kev noj qab haus huv.
References
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