Sinadaran tsirrai masu tushe mai ƙarfi da tushe mai matakai da yawa har yanzu ba a saba gani ba a cikin rukunin kula da nauyi. Theolim, wani sinadari na musamman da NaturMed Scientific ta ƙirƙira, an kimanta shi ta hanyar bincike na asibiti da na asibiti. Wannan labarin ya taƙaita abin da shaidar da aka buga a halin yanzu ke nunawa, abin da ba ya nuna, da kuma dalilin da ya sa bayanin lafiyar ya shafi masu amfani.
Menene Theolim?
Theolim wani haɗin sinadarai ne na asali wanda aka yi da lasisi wanda aka samo daga tsirrai guda biyu: ƙashin Key lime (Citrus aurantifolia) da kuma irin Koko (Theobroma cacao), an haɗa su a rabon 2: 1. Duk kayan tushen abinci ne da ake amfani da su sosai tare da dogon tarihin amfani da ɗan adam. Sinadarin da aka gama an daidaita shi zuwa mafi ƙarancin matakan citric acid (5.0%), theobromine (0.5%), da hesperidin (0.3%), kuma ana samar da shi a cikin cibiyar da aka ba da takardar shaidar Ayyukan Masana'antu (Kundimi et al., 2024).
An zaɓi tsarin ne bayan wani tsari na tantancewa mai tsari wanda aka kimanta abubuwan da aka samo daga tsirrai sama da 1,000. An gano cewa haɗin waɗannan abubuwan biyu yana haifar da sakamako mafi girma fiye da kowane sinadari a ware, wani siffa da aka kira a fannin ilimin kimiyyar magunguna a matsayin haɗin gwiwa (Kundimi et al., 2024).
Mataki na 1: Binciken Kwayoyin Halitta da Dabbobi
A cikin wani bincike da aka buga a cikin Journal of the American Nutrition Association, Kundimi et al. (2024) sun binciki Theolim a cikin al'adun ƙwayoyin kitse na beraye da kuma a cikin samfurin dabba na kiba da abinci ke haifarwa. A cikin ƙwayoyin kitse, an lura da Theolim yana tallafawa samar da fibroblast growth factor-21 (FGF-21), furotin mai siginar metabolism wanda ke da hannu a cikin daidaita kuzari, da kuma tallafawa bayyanar furotin-1 (UCP-1) da beta-3 adrenergic receptor (β3-AR), duka sunadaran da ke da alaƙa da aikin thermogenic a cikin kyallen adipose. An lura da waɗannan tasirin zuwa babban mataki tare da haɗakar cirewa fiye da tare da ɗayan sinadaran kaɗai (Kundimi et al., 2024).
A cikin beraye da aka ciyar da abinci mai yawan kitse, ƙarin abinci ta baki na tsawon kwanaki 28 yana da alaƙa da ƙaruwar kashe kuzarin da ake yi a lokacin hutu da raguwar nauyin jiki da kuma jimillar kitse idan aka kwatanta da dabbobin da ba a ƙara musu ba. Yawan cin abinci bai bambanta sosai tsakanin ƙungiyoyi ba a wannan lokacin (Kundimi et al., 2024). Kamar yadda yake tare da duk binciken dabbobi, waɗannan binciken ba za a iya amfani da su kai tsaye ga sakamakon ɗan adam ba kuma an fi fahimtar su a matsayin shaidar farko ta injiniya.
Mataki na 2: Gwajin Mutuwa Mai Tsanani
Nazarin ɗan adam na farko an yi shi ne da wani gwaji na crossover wanda aka yi shi bazuwar, wanda aka yi masa laƙabi da placebo, wanda ya ƙunshi manya 60 masu kiba masu shekaru 20 zuwa 39 (BMI 25 zuwa 29.9 kg/m²), wanda aka buga a cikin Food & Nutrition Research (Ammatalli et al., 2024). Mahalarta sun karɓi capsule guda ɗaya na Theolim 450 MG ko placebo mai daidaitawa, kuma an auna ƙimar metabolism na hutawa (RMR) ta amfani da calorimetry kai tsaye a minti 60, 120, da 180 bayan shan magani, da kuma lokacin da kuma bayan zaman motsa jiki mai matsakaici washegari.
RMR a cikin rukunin Theolim ya fi placebo girma sosai a kididdiga a maki na minti 120 da minti 180. Haka kuma an lura cewa iskar shaka ta kitse, wato yadda jiki ke amfani da kitse a matsayin tushen mai, ta fi yawa a cikin rukunin Theolim a lokacin hutawa da kuma a cikin mintuna 20 bayan motsa jiki, idan aka kwatanta da placebo (Ammatalli et al., 2024).
Hawan jini da bugun zuciya ba su bambanta sosai tsakanin ƙungiyoyi a cikin kowane yanayi ba, kuma duk ƙima sun kasance a cikin ma'aunin ilimin halittar jiki na yau da kullun a duk tsawon lokacin. Mahalarta ƙungiyar Theolim sun kuma sami ƙananan maki akan tambayoyin da aka tabbatar da rikicewar yanayi yayin motsa jiki idan aka kwatanta da ƙungiyar placebo (Ammatalli et al., 2024). Ba a bayar da rahoton wani mummunan lamari ba. Marubutan sun lura cewa wannan bincike ne na ɗan gajeren lokaci, kuma za a buƙaci bincike na dogon lokaci don tantance tasirin da ya daɗe.
Mataki na 3: Gwaji Mai Kula da Makonni 16
Shaidar da ta fi muhimmanci ga ɗan adam zuwa yanzu ta fito ne daga wani gwaji da aka yi a wurare da dama, wanda aka yi wa mutane 120 masu kiba masu shekaru 25 zuwa 55, wanda aka buga a cikin Food & Nutrition Research (Chadalavada et al., 2025).
Mahalarta sun sami ko dai 450 MG/rana na Theolim ko kuma wani placebo da ya yi daidai na tsawon makonni 16, sun bi abincin da suka saba ci, kuma an umarce su da su yi tafiya na minti 30 kwana biyar a mako. An lura da yawan kalori da ake ci a ko'ina kuma bai bambanta sosai tsakanin ƙungiyoyi ba.
Nauyin jiki da abun da ke ciki: Bayan makonni 16, mutanen da suka sha Theolim sun rasa nauyi a matsakaici (kimanin kilogiram 4.25) fiye da waɗanda suka sha placebo (kimanin kilogiram 1). Hakanan sun sami raguwar kitse a jiki (kimanin kilogiram 4.28 idan aka kwatanta da kilogiram 0.85), kuma BMI ɗinsu ya ragu sosai. Yawan tsoka ya kasance iri ɗaya, tare da ƙaramin ƙaruwa a cikin ƙungiyar Theolim da ƙaramin raguwa a cikin ƙungiyar placebo (Chadalavada et al., 2025).
Kugu da kuma kewayen kugu: An rage kewayen kugu da matsakaicin 4.32 cm a cikin ƙungiyar Theolim idan aka kwatanta da 2.10 cm a cikin placebo, da kuma kewayen kugu da 3.16 cm idan aka kwatanta da 1.31 cm bi da bi, duka biyun suna da mahimmanci a kididdiga idan aka kwatanta da placebo a mako na 16 (Chadalavada et al., 2025).
Ragewar metabolism na hutawa: Yawan motsa jiki na hutawa ya ƙaru daga farkon allurai da matsakaicin 459 kcal/rana a cikin ƙungiyar Theolim a mako na 16, idan aka kwatanta da kimanin 102 kcal/rana a cikin ƙungiyar placebo (p < 0.001 idan aka kwatanta da placebo). Hakanan an rage yawan musanyar numfashi sosai a cikin ƙungiyar Theolim a makonni na 8 da 16, wanda zai iya nuna ƙaruwar amfani da kitse a matsayin tushen kuzari, kodayake fassarar asibiti na wannan ma'aunin a ware yana da iyaka (Chadalavada et al., 2025).
Alamar halitta: GLP-1 na jini, wani sinadari mai aiki a cikin daidaita ci da aikin metabolism, ya karu da kusan kashi 33% daga tushen sa a cikin ƙungiyar Theolim a mako na 16 (p < 0.001 idan aka kwatanta da tushen sa; p < 0.05 idan aka kwatanta da placebo). Adiponectin na jini ya karu da kusan kashi 52% daga tushen sa, yayin da ghrelin ya ragu sosai idan aka kwatanta da tushen sa da placebo.
Bayanin lipid da kuma tasirin insulin: Cholesterol na LDL, rabon LDL/HDL, da HOMA-IR, alamar da aka yi amfani da ita don kimanta juriyar insulin, duk sun ragu sosai a cikin ƙungiyar Theolim a mako na 16 idan aka kwatanta da placebo (Chadalavada et al., 2025).
Muhimmancin waɗannan canje-canjen alamar alama a cikin mahallin ƙarin abinci yana buƙatar ƙarin bincike mai zaman kansa.
Ba a sami wani mummunan sakamako mai illa ba. Ƙananan abubuwan da suka faru kamar ciwon kai, tashin zuciya, da tari sun kasance iri ɗaya tsakanin ƙungiyoyi, kuma duk sigogin jini da na sinadarai sun kasance cikin ma'aunin al'ada a ko'ina (Chadalavada et al., 2025).
Kimanta Tsaron Kafin Asibiti
Nazarin aminci kafin asibiti da aka gudanar a ƙarƙashin jagororin OECD bai gano wata shaida ta guba mai yawa ko lalacewar kwayoyin halitta da ke da alaƙa da Theolim a allurai da aka gwada ba. Nazarin dabbobi masu yawan shan ƙwayoyi da na dogon lokaci bai ba da rahoton wani mummunan tasiri ko rashin lafiya mai mahimmanci a cikin alamun lafiya, aikin gabobi, ko tsarin nama ba (Kundimi et al., 2023).
Ma'ana da Iyakoki
An gudanar da gwaje-gwajen asibiti a Indiya kuma wani ɓangare na masana'antu ne suka ɗauki nauyinsu. Duk da cewa an yi rijista kuma an buga su a cikin mujallu da aka yi nazari a kansu bisa ga ƙa'idodin Good Clinical Practice, kwafi mai zaman kansa a cikin al'ummar Turai zai ƙara amincewa da sakamakon. Gwaje-gwajen sun haɗa da manya masu kiba waɗanda ke da BMI tsakanin 25 zuwa 29.9 kg/m², kuma sakamakon ba zai shafi mutanen da ke wajen wannan matakin ba ko kuma waɗanda ke da mawuyacin hali na lafiya. An lura da tasirin tare da cin abinci na yau da kullun da kuma shirin tafiya mai sauƙi (Chadalavada et al., 2025).
lura: Theolim sinadari ne na ƙarin abinci, ba magani mai lasisi ba, kuma ba a yi nufin gano cutar ba, magani, warkarwa, ko hana ta. Ana ba da shawara ga masu amfani da ke da matsalolin lafiya ko waɗanda ke shan magani su tuntuɓi ƙwararren masanin kiwon lafiya kafin amfani da shi.
References
Ammatalli, NKR, Kuricheti, SSSK, Veeramachaneni, S., Koo, YK, Ramanathan, G. da Yalamanchi, A. (2024) 'Haɗin kai na Citrus aurantifolia fatar 'ya'yan itace da kuma Theobroma cacao Karin sinadarin iri yana ƙara yawan metabolism a cikin mutane masu kiba: wani bincike da aka gudanar bazuwar, wanda aka sarrafa ta hanyar placebo, Binciken Abinci & Abinci, 68, labarin 10745. Akwai a: https://doi.org/10.29219/fnr.v68.10745
Chadalavada, A., Koo, YK, Kim, S., Veeramachaneni, S., Ramanathan, G. da Yalamanchi, A. (2025) 'A thermogenic Botanical abun da ke ciki Citrus aurantifolia fatar 'ya'yan itace da kuma Theobroma cacao 'Ya'yan iri suna inganta tsarin jiki a cikin manya masu kiba: binciken asibiti', Binciken Abinci & Abinci, 69, labarin 12159. Akwai a: https://doi.org/10.29219/fnr.v69.12159
Kundimi, S., Chinta, G., Alluri, KV, Golakoti, T., Veeramachaneni, S., Ramanathan, G. da Sengupta, K. (2023) 'Preclinical aminci kimantawa na LN19183: m, subchronic, dermal, ido da genotoxicity R. Centre, Vijayawada, India.
Kundimi, S., Chinta, G., Alluri, KV, Golakoti, T., Veeramachaneni, S., Ramanathan, G. da Sengupta, K. (2024) 'Haɗaɗɗen kayan lambu yana ƙara yawan kuzarin hutawa kuma yana rage yawan kitse a cikin berayen da aka ciyar da abinci mai yawan kitse', Jaridar Ƙungiyar Abinci ta Amirka, 43(3), shafi na 286–295. Akwai a: https://doi.org/10.1080/27697061.2023.2280777
Disclaimer: Ba a tantance wannan bayanin ta EFSA, KFDA ko FDA ba. Ba a yi nufin wannan samfurin don gano cutar ba, magani, warkarwa, ko hana kowace cuta. Duk da cewa bayanin da aka bayar ya dogara ne akan nassoshi masu inganci, ba ma yin wani takamaiman da'awa ko garanti. Yana da mahimmanci a tuntuɓi mai ba da shawara kan harkokin kiwon lafiya don shawara da jagora na musamman da suka shafi lafiyar ku.
