Nattokinase wani enzyme ne da ake samu ta halitta wanda aka samo daga natto, wani abincin gargajiya na Japan wanda aka yi ta hanyar fermenting waken soya tare da Bacillus subtilis natto. Ya sami sha'awar kimiyya saboda rawar da yake takawa wajen tallafawa lafiyar zuciya da jijiyoyin jini, lafiyar kwararar jini, da kuma yadda ake zagayawa a jiki. Nattokinase sananne ne musamman saboda ayyukansa na fibrinolytic, ma'ana yana iya taimakawa wajen tallafawa tsarin halitta na jiki na rushe fibrin, wani furotin da ke da hannu wajen samar da gudan jini.
Ba kamar sauran sinadaran shuka ba, nattokinase sinadari ne mai aiki wanda aka yi shi da enzyme. An yi nazari a kansa game da tasirinsa ga hawan jini, danko a jini, alamomin da suka shafi gudan jini, metabolism na lipid, da lafiyar jijiyoyin jini. Duk da haka, shaidar da ake da ita har yanzu tana ci gaba, kuma sakamakon ya bambanta dangane da yawan da za a sha, ƙirar binciken, yawan jama'a, da tsawon lokacin da za a sha. Ga wasu fa'idodi da dama na nattokinase ga lafiya bisa ga binciken kimiyya.
1. Yana Taimakawa Lafiyar Gudanar Jini da Ayyukan Fibrinolytic
Nattokinase na iya taimakawa wajen samar da ingantaccen zagayawar jini ta hanyar taimakawa jiki wajen kula da daidaiton fibrin da kuma hanyoyin da ke wargaza gudan jini.
A cikin wani sharhi mai taken Nattokinase: Maganin hana thrombosis na baki don Rigakafin Cututtukan Zuciya da Jijiyoyin Jiki, masu bincike sun bayyana nattokinase a matsayin enzyme na fibrinolytic wanda ke da yuwuwar tallafawa zuciya da jijiyoyin jini. Binciken ya bayyana cewa nattokinase na iya taimakawa wajen wargaza fibrinolytic kai tsaye kuma yana iya tallafawa tsarin fibrinolytic na jiki ta hanyar yin tasiri ga plasmin da sauran hanyoyin da suka shafi gudan jini. Waɗannan hanyoyin suna nuna cewa nattokinase na iya taka rawa wajen tallafawa kwararar jini mai kyau da aikin jijiyoyin jini (Weng et al., 2017).
Wani bita, Nattokinase: Madadin Alkawari a Rigakafi da Maganin Cututtukan Zuciya da Jijiyoyin Jini, ya tattauna nattokinase a matsayin ɗaya daga cikin abubuwan da suka fi aiki a cikin natto. Marubutan sun nuna tasirinsa kan fibrinolysis, hawan jini, metabolism na lipid, da alamomin da suka shafi atherosclerosis. Duk da haka, sun kuma lura cewa ana buƙatar ƙarin nazarin ɗan adam don tabbatar da mahimmancinsa na asibiti, daidaitaccen adadin da ya dace, da aminci na dogon lokaci a cikin al'ummomi daban-daban (Chen et al., 2018).
2. Zai Iya Taimakawa Wajen Kiyaye Hawan Jini Mai Kyau
An yi nazari kan rawar da Nattokinase ke takawa wajen tallafawa hawan jini na yau da kullun, musamman a cikin mutanen da ke da hauhawar hawan jini.
A wani gwaji da aka gudanar bazuwar, wanda aka yi wa makafi biyu, wanda aka sarrafa shi ta hanyar placebo, masu bincike sun yi nazari kan manya 86 masu shekaru 20 zuwa 80 da ke fama da hawan jini na systolic wanda ba a yi masa magani ba tsakanin 130 da 159 mmHg. Mahalarta sun sami ko dai nattokinase a 2,000 FU a rana ko kuma placebo na tsawon makonni 8. Mahalarta saba'in da uku sun kammala binciken. Idan aka kwatanta da placebo, nattokinase yana da alaƙa da raguwar hawan jini na systolic da diastolic, tare da canje-canje na kusan -5.55 mmHg da -2.84 mmHg, bi da bi. Binciken ya kuma lura da raguwar ayyukan renin na plasma, yana nuna yiwuwar wata hanya da ta shafi daidaita hawan jini (Kim et al., 2008).
A wani bincike da aka gudanar a Arewacin Amurka, wanda aka gudanar da shi bazuwar, wanda aka yi shi da makafi biyu, an gudanar da shi ta hanyar placebo, mahalarta 79 da suka kamu da hawan jini sun sha ko dai 100 mg na nattokinase kowace rana ko kuma placebo na tsawon makonni 8. Binciken ya binciki hawan jini da alamomin da ke da alaƙa da haɗarin zuciya da jijiyoyin jini, gami da von Willebrand factor. Binciken ya nuna cewa shan nattokinase yana da alaƙa da raguwar hawan jini da raguwar von Willebrand factor, wani alama da ke da alaƙa da lafiyar jijiyoyin jini da aikin zubar jini (Jensen et al., 2016).
Waɗannan nazarin sun nuna cewa nattokinase na iya taimakawa wajen daidaita hawan jini a wasu ƙungiyoyi. Duk da haka, bai kamata a ɗauki shi a matsayin madadin magungunan hana hawan jini ko kulawar likita da aka rubuta ba.
3. Zai Iya Taimakawa Daidaiton Alamar Hadarin Zuciya da Jijiyoyin Jiki
Nattokinase na iya taimakawa wajen tallafawa lafiyar zuciya da jijiyoyin jini ta hanyar yin tasiri ga zaɓaɓɓun alamomi da suka shafi zubar jini, aikin jijiyoyin jini, da zagayawar jini.
Binciken da Jensen et al. (2016) suka yi ya fi dacewa musamman domin ba wai kawai ya binciki hawan jini ba, har ma ya auna von Willebrand factor da platelet factor-4. Von Willebrand factor yana da hannu a mannewar platelet da samuwar gudan jini. Rage wannan alamar na iya nuna tasirin tallafi ga daidaiton jijiyoyin jini da jijiyoyin jini. Duk da haka, wannan ba yana nufin nattokinase yana hana faruwar cututtukan zuciya da jijiyoyin jini ba, domin ana buƙatar gwaje-gwaje na asibiti masu girma da tsayi don tabbatar da irin waɗannan sakamakon.Jensen et al., 2016).
Wani bita da nazari mai tsari na shekarar 2023 mai taken Nattokinase Supplementation da Cardiovascular Risk Factors ya kimanta gwaje-gwajen da aka sarrafa bazuwar kan nattokinase da alamomin zuciya da jijiyoyin jini. Bitar ta gano cewa ƙarin nattokinase yana da alaƙa da raguwar hawan jini na systolic da diastolic. Duk da haka, marubutan sun kuma lura cewa shaidar wasu alamomi, gami da sakamakon lipid da coagulation, ba ta da daidaito a cikin binciken (Li et al., 2023).
Gabaɗaya, nattokinase na iya tallafawa zaɓaɓɓun alamun cututtukan zuciya da jijiyoyin jini, amma tasirinsa ya dogara ne akan yawan mutanen da aka yi nazari a kansu, yawan da ake buƙata, daidaiton samfurin, da tsawon lokacin amfani da shi.
4. Zai Iya Taimakawa Wajen Taimakawa Ga Ci Gaban Lipid Metabolism da Lafiyar Jijiyoyi
Wasu bincike sun nuna cewa nattokinase na iya taimakawa wajen daidaita metabolism na lipid da lafiyar jijiyoyin jini, amma shaidar ba ta da cikakken daidaito.
A wani bincike na asibiti kan cutar atherosclerosis da kuma yawan kitse a cikin jijiyoyin carotid, an binciki ƙarin nattokinase don tasirinsa akan kauri na carotid intima-media, girman plaque, da kuma bayanin lipid. Binciken ya nuna cewa nattokinase na iya rage ma'aunin da ke da alaƙa da plaque da kuma inganta wasu alamun lipid a cikin mahalarta da ke fama da atherosclerosis da hauhawar lipids (Ren et al., 2017).
Wani bincike da aka yi daga baya ya binciki yawan shan nattokinase a kowace rana, 10,800 FU a kowace rana, dangane da ci gaban atherosclerosis da hyperlipidemia. Masu binciken sun ba da rahoton cewa wannan maganin yana da alaƙa da inganta yanayin lipid da matakan da suka shafi atherosclerosis. Duk da haka, bai kamata a yi amfani da manyan allurai ga duk samfuran nattokinase ko ƙarin allurai na yau da kullun ba tare da yin nazari mai kyau ba (Chen et al., 2022).
A lokaci guda kuma, ba duk bincike suka nuna sakamako mai kyau ba. Nazarin Rigakafin Nattokinase Atherothrombotic, wani gwaji da aka gudanar bazuwar a cikin mutane masu lafiya waɗanda ke da ƙarancin haɗarin kamuwa da cututtukan zuciya, ya gano cewa ƙarin nattokinase bai yi tasiri sosai ga ci gaban atherosclerosis ba, hawan jini, ko alamun dakin gwaje-gwaje bayan matsakaicin lokacin magani na shekaru 3 (Hodis da sauransu, 2021).
Wannan bambancin ya nuna cewa nattokinase na iya zama mafi dacewa a cikin zaɓaɓɓun mutane, musamman waɗanda ke da takamaiman abubuwan da ke haifar da haɗarin zuciya da jijiyoyin jini, maimakon mutane masu lafiya waɗanda ba su da haɗarin kamuwa da cutar.
5. Zai Iya Ba da Tallafi a Matsayin Wani ɓangare na Tsarin Lafiyar Zuciya
A wasu lokutan ana nazarin Nattokinase tare da wasu sinadarai masu aiki, musamman a binciken lafiyar zuciya.
A cikin wani gwaji da aka gudanar a shekarar 2024, wanda aka yi wa lakabi da placebo, masu bincike sun yi nazarin nattokinase tare da shinkafar yisti ja a cikin marasa lafiya da ke fama da cututtukan jijiyoyin zuciya. Binciken ya binciki tasirin rage kitse, rage hawan jini, da kuma tasirin thrombosis. Sakamakon ya nuna cewa haɗin gwiwar na iya inganta wasu sigogin zuciya, kodayake yana da mahimmanci a lura cewa wannan binciken haɗin gwiwa ne. Saboda haka, ba za a iya danganta fa'idodin da nattokinase kaɗai ba (Liu et al., 2024).
Wannan nau'in bincike yana da mahimmanci saboda lafiyar zuciya da jijiyoyin jini yana shafar abubuwa da yawa, ciki har da abinci, motsa jiki, matakan lipid, hawan jini, kumburi, damuwa ta oxidative, da kwayoyin halitta. Nattokinase na iya dacewa da dabarun lafiya mai faɗi, amma ya kamata a sanya shi a matsayin sinadari mai tallafawa maimakon mafita mai zaman kansa.
6. Gabaɗaya an yarda da shi sosai, amma ana buƙatar kulawa
An yi imanin cewa Nattokinase ya fi dacewa a cikin binciken ɗan adam da yawa, amma yana buƙatar amfani da shi da kyau saboda tasirinsa ga hanyoyin zubar jini.
Wani bincike na asibiti na gaske ya kimanta nattokinase a 100 MG kowace rana ga marasa lafiya da aka kwantar a asibiti. Masu binciken sun ba da rahoton abubuwan da aka lura da su waɗanda ke goyon bayan amincin amfani da nattokinase a wannan yanayin, kodayake kulawar likita ta mutum ɗaya tana da mahimmanci, musamman ga mutanen da ke shan magungunan hana zubar jini ko magungunan hana zubar jini (Gallelli da sauransu, 2021).
Tunda nattokinase na iya yin tasiri ga fibrinolysis da alamomin da suka shafi gudan jini, ƙila ba zai dace da kowa ba. Mutanen da ke shan magungunan rage jini, aspirin, magungunan hana ɗaukar jini, ko magungunan hana zubar jini, da kuma waɗanda ke fama da matsalolin zubar jini, tiyatar da ke tafe, ciki, ko kuma mawuyacin hali, ya kamata su nemi shawarar likita kafin su yi amfani da nattokinase.
Nattokinase wani enzyme ne na musamman da aka samo daga waken soya da aka girbe kuma an fi saninsa da rawar da yake takawa wajen tallafawa lafiyar zuciya da jijiyoyin jini. Manyan fannoni na bincike da yake yi sun haɗa da:
- Tallafin kwararar jini mai lafiya
- Ayyukan Fibrinolytic
- Ma'aunin hawan jini
- Tallafin alamar jijiyoyi
- Metabolism na lipid da lafiyar jijiyoyin jini a cikin zaɓaɓɓun mutane
Binciken da ake da shi yana da kyau, amma ba shi da cikakken daidaito. Wasu nazarin sun nuna ci gaba mai ma'ana a hawan jini, aikin fibrinolytic, da alamun zuciya da jijiyoyin jini, yayin da wasu kuma suna nuna ƙarancin tasiri ko rashin tasiri, musamman ga mutanen da ke da ƙarancin haɗari. Wannan yana nuna cewa nattokinase na iya aiki daban-daban dangane da yanayin lafiyar mutum, yawan shansa, tsawon lokacinsa, da ingancin samfurin.
Ya kamata a ɗauki Nattokinase a matsayin sinadari mai taimakawa wajen aiki maimakon magani ko magani. Idan aka yi amfani da shi da kyau, yana iya zama ƙarin amfani ga magungunan lafiyar zuciya da jijiyoyin jini, musamman waɗanda suka mayar da hankali kan zagayawar jini, tsufa mai kyau, da kuma daidaita metabolism.
Disclaimer: Ba a tantance wannan bayanin daga EFSA, KFDA ko FDA ba. Ba a yi nufin wannan samfurin don gano cutar ba, magani, warkarwa, ko hana kowace cuta. Duk da cewa bayanin da aka bayar ya dogara ne akan nassoshi masu inganci, ba ma yin wani takamaiman da'awa ko garanti. Yana da mahimmanci a tuntuɓi mai ba da shawara kan harkokin kiwon lafiya don shawara da jagora na musamman da suka shafi lafiyar ku.
References
- Chen, H., McGowan, EM, Ren, N., Lal, S., Nassif, N., Shad-Kaneez, F., Qu, X. da Lin, Y., 2018. Nattokinase: Wani madadin da ke da kyau wajen rigakafi da magance cututtukan zuciya da jijiyoyin jini. Fahimtar Alamar Halitta, 13, shafi 1-8.
- Chen, H., McGowan, EM, Ren, N., Lal, S., Nassif, N., Shad-Kaneez, F., Qu, X. da Lin, Y., 2022. Gudanar da ingantaccen ci gaban atherosclerosis da hyperlipidemia tare da nattokinase. Gabatarwa a Magungunan cututtukan zuciya.
- Gallelli, G., Cione, E., Caroleo, MC, Carullo, G., Genchi, G., Rende, P. da Citraro, R., 2021. Bayanan da aka rubuta a rayuwa ta ainihi suna tallafawa amincin nattokinase ga marasa lafiya da ke fama da cututtukan jijiyoyin jini. Kayan shafawa, 13 (6), shafi na 2031.
- Hodis, HN, Mack, WJ, Dustin, L., Mahrer, PR da Azen, SP, 2021. Nazarin rigakafin Nattokinase atherothrombotic: Gwaji mai sarrafawa bazuwar. Ilimin Jini da Ƙarfin Jini na Asibiti, 78(4), shafi na 339–353.
- Jensen, GS, Lenninger, M., Ero, MP da Benson, KF, 2016. Shan nattokinase yana da alaƙa da raguwar hawan jini da kuma von Willebrand factor, wani alamar haɗarin zuciya da jijiyoyin jini: Sakamako daga gwajin asibiti na Arewacin Amurka mai cibiya da yawa. Tsarin Haɗakar ..., 9, shafi 95-104.
- Kim, JY, Gum, SN, Paik, JK, Lim, HH, Kim, KC, Ogasawara, K., Inoue, K., Park, S., Jang, Y. da Lee, JH, 2008. Tasirin nattokinase akan hawan jini: Gwaji mai tsari da aka tsara. Binciken Hawan Jini, 31(8), shafi na 1583–1588.
- Li, X., Zheng, X., Liu, Y. da Zhang, Y., 2023. Karin Nattokinase da abubuwan da ke haifar da haɗarin zuciya da jijiyoyin jini: Bita mai tsari da nazarin meta. Reviews a cikin Magungunan cututtukan zuciya, 24 (8), shafi na 234.
- Liu, M., Zhang, H., Wang, Y., Li, X. da Chen, J., 2024. Tasirin rage kiba, rage hawan jini, da kuma hana thrombosis na nattokinase tare da shinkafar yisti ja a cikin marasa lafiya da ke fama da cutar jijiyoyin zuciya mai karko: Gwaji mai sarrafa placebo, wanda aka yi niyya, wanda aka yi niyya ta hanyar da ba a saba gani ba. Faransanci a Gina Jiki.
- Ren, NN, Chen, HJ, Li, Y., McGowan, E. da Lin, YG, 2017. Nazarin asibiti kan tasirin nattokinase akan atherosclerosis na jijiyoyin carotid da hyperlipidaemia. Zhonghua Yi Xue Za Zhi, 97(26), shafi na 2038–2042.
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